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- W2015220242 abstract "Morphogenesis, homeostasis, and regeneration of epithelial tissues rely on the accurate orientation of cell divisions, which is specified by the mitotic spindle axis. To remain in the epithelial plane, symmetrically dividing epithelial cells align their mitotic spindle axis with the plane. Here, we show that this alignment depends on epithelial cell-cell communication via semaphorin-plexin signaling. During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle, leading to severe defects in epithelial architecture and function. Analyses of a series of transgenic and knockout mice indicate that Plexin-B2 controls the cell division axis by signaling through its GTPase-activating protein (GAP) domain and Cdc42. Our data uncover semaphorin-plexin signaling as a central regulatory mechanism of mitotic spindle orientation necessary for the alignment of epithelial cell divisions with the epithelial plane." @default.
- W2015220242 created "2016-06-24" @default.
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- W2015220242 date "2015-05-01" @default.
- W2015220242 modified "2023-10-18" @default.
- W2015220242 title "Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair" @default.
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- W2015220242 doi "https://doi.org/10.1016/j.devcel.2015.02.001" @default.
- W2015220242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25892012" @default.
- W2015220242 hasPublicationYear "2015" @default.
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