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- W2015221103 abstract "Micronemes are secretory organelles of the invasive stages of apicomplexan parasites and contain proteins that are important for parasite motility and host cell invasion. We have examined the induction of microneme secretion in the coccidian Eimeria tenella. When sporozoites were added to MDBK cells in culture, microneme proteins were secreted, capped backwards over the parasite surface and deposited onto underlying host cells from the posterior end of gliding parasites. Induction of secretion was also achieved by the addition of foetal calf serum, or purified albumin, to extracellular sporozoites. Microneme secretion per se was not dependent on parasites being able to move or to invade host cells. However, in the presence of cytochalasin D, which disrupts actin polymerisation and prevents parasite movement, microneme proteins were secreted from the apical tip but were not capped backwards over the sporozoite surface. These observations support the hypothesis that microneme proteins function as ligands which, when secreted out onto the parasite surface, form a link, either directly or indirectly, between the sub-pellicular actin myosin cytoskeletal motor of the parasite and the surface of target host cells." @default.
- W2015221103 created "2016-06-24" @default.
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- W2015221103 date "2000-10-01" @default.
- W2015221103 modified "2023-09-24" @default.
- W2015221103 title "Induction of secretion and surface capping of microneme proteins in Eimeria tenella" @default.
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- W2015221103 doi "https://doi.org/10.1016/s0166-6851(00)00280-2" @default.
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