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- W2015221108 abstract "Purpose: Localization of hippocampal paroxysmal activities in temporal lobe epilepsy (TLE) by means of dipole modeling has often been criticized because of the supposed inaccuracy of this technique in localizing deep sources of EEG signals. This study aimed at assessing the relevance of mesio-temporal dipoles, as identified by modeling of scalp recorded spikes in TLE. Methods: Surface and depth EEG activities were simultaneously recorded using scalp and intracranial electrodes implanted through the foramen ovale (FO) in 3 patients with refractory TLE seizures. Intracranial FO spikes were used as triggers for scalp EEG averaging. The averaged signals were modeled by current dipoles, the localization of which were fused with patients' 3D-MRI. Results: Individual FO spikes were undetectable on visual analysis of raw scalp EEG but were reflected by low-amplitude scalp EEG transients on averaged signal. Dipole modeling of this EEG deflection consistently identified a mesio-limbic source in a position close to that of the FO pole recording the intracranial spike with its maximal amplitude. Conclusion: This result suggests that mesio-temporal sources can be accurately localized by modeling the signals recorded on the scalp, thus validating the anatomical and clinical relevance of hippocampal sources identified by modeling scalp interictal averaged spikes in TLE." @default.
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- W2015221108 title "Topographical reliability of mesio-temporal sources of interictal spikes in temporal lobe epilepsy" @default.
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- W2015221108 doi "https://doi.org/10.1016/s0013-4694(98)00055-8" @default.
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