Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015227598> ?p ?o ?g. }
- W2015227598 endingPage "46" @default.
- W2015227598 startingPage "40" @default.
- W2015227598 abstract "Ochratoxin A (OTA) is a fungal metabolite with controversial immunomodulatory effects. A prolonged in vivo exposure to the mycotoxin may result in impaired immunity and decreased resistance to infections. In the present study, OTA modulation of lipopolysaccharide (LPS)-induced inflammatory process is described in the macrophagic cell line, J774A.1 in order to better understand the mechanisms underlying OTA immunotoxicity. OTA (30 nM–100 μM) induces a time and concentration dependent cytotoxic effect, increased when cells were co-stimulated with LPS (100 ng/ml), a concentration that alone did not modify the cellular viability. Moreover, OTA (3 μM) alone induces a significant increase in cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, while at the highest concentration (10 μM) a reduced expression of both enzymes was shown, consistently with the mycotoxin cytotoxic profile. The role of nuclear factor-kB (NF-kB) in the mycotoxin effect was also demonstrated. Conversely, when cells were co-stimulated with LPS, OTA showed a concentration-dependent reduction of COX-2 and iNOS expression and their respective metabolites (PGE2 and NO). These results confirm the pro-inflammatory role of OTA by itself, and demonstrate the impaired capability of OTA-treated macrophages to respond properly to noxious stimuli, such as LPS, mimicking the environmental co-exposure to both compounds." @default.
- W2015227598 created "2016-06-24" @default.
- W2015227598 creator A5006866619 @default.
- W2015227598 creator A5007489715 @default.
- W2015227598 creator A5033436256 @default.
- W2015227598 creator A5056176641 @default.
- W2015227598 creator A5060325672 @default.
- W2015227598 creator A5086708669 @default.
- W2015227598 date "2008-09-10" @default.
- W2015227598 modified "2023-09-25" @default.
- W2015227598 title "Differential modification of inflammatory enzymes in J774A.1 macrophages by ochratoxin A alone or in combination with lipopolysaccharide" @default.
- W2015227598 cites W1532918004 @default.
- W2015227598 cites W1587123510 @default.
- W2015227598 cites W1929009802 @default.
- W2015227598 cites W1935401387 @default.
- W2015227598 cites W1964979213 @default.
- W2015227598 cites W1974026314 @default.
- W2015227598 cites W1978711875 @default.
- W2015227598 cites W1983668987 @default.
- W2015227598 cites W1983965919 @default.
- W2015227598 cites W1989351016 @default.
- W2015227598 cites W1990802251 @default.
- W2015227598 cites W1990896627 @default.
- W2015227598 cites W1996565900 @default.
- W2015227598 cites W1999527257 @default.
- W2015227598 cites W2002328584 @default.
- W2015227598 cites W2007690138 @default.
- W2015227598 cites W2009151641 @default.
- W2015227598 cites W2009813023 @default.
- W2015227598 cites W2015367968 @default.
- W2015227598 cites W2016013190 @default.
- W2015227598 cites W2016713201 @default.
- W2015227598 cites W2018556115 @default.
- W2015227598 cites W2018897112 @default.
- W2015227598 cites W2018913451 @default.
- W2015227598 cites W2019175254 @default.
- W2015227598 cites W2019632917 @default.
- W2015227598 cites W2026598436 @default.
- W2015227598 cites W2030514238 @default.
- W2015227598 cites W2032336668 @default.
- W2015227598 cites W2034415027 @default.
- W2015227598 cites W2037514216 @default.
- W2015227598 cites W2040470926 @default.
- W2015227598 cites W2040934830 @default.
- W2015227598 cites W2047948456 @default.
- W2015227598 cites W2050760026 @default.
- W2015227598 cites W2054590798 @default.
- W2015227598 cites W2057792332 @default.
- W2015227598 cites W2058187173 @default.
- W2015227598 cites W2058220747 @default.
- W2015227598 cites W2060360020 @default.
- W2015227598 cites W2074105606 @default.
- W2015227598 cites W2075886730 @default.
- W2015227598 cites W2089747387 @default.
- W2015227598 cites W2092410759 @default.
- W2015227598 cites W2111304767 @default.
- W2015227598 cites W2114918609 @default.
- W2015227598 cites W2123550256 @default.
- W2015227598 cites W2143335977 @default.
- W2015227598 cites W2148599988 @default.
- W2015227598 cites W2157007916 @default.
- W2015227598 cites W2165197441 @default.
- W2015227598 cites W2410367108 @default.
- W2015227598 cites W2461339281 @default.
- W2015227598 doi "https://doi.org/10.1016/j.toxlet.2008.06.866" @default.
- W2015227598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18647641" @default.
- W2015227598 hasPublicationYear "2008" @default.
- W2015227598 type Work @default.
- W2015227598 sameAs 2015227598 @default.
- W2015227598 citedByCount "29" @default.
- W2015227598 countsByYear W20152275982012 @default.
- W2015227598 countsByYear W20152275982013 @default.
- W2015227598 countsByYear W20152275982014 @default.
- W2015227598 countsByYear W20152275982015 @default.
- W2015227598 countsByYear W20152275982016 @default.
- W2015227598 countsByYear W20152275982017 @default.
- W2015227598 countsByYear W20152275982019 @default.
- W2015227598 countsByYear W20152275982020 @default.
- W2015227598 countsByYear W20152275982021 @default.
- W2015227598 countsByYear W20152275982022 @default.
- W2015227598 crossrefType "journal-article" @default.
- W2015227598 hasAuthorship W2015227598A5006866619 @default.
- W2015227598 hasAuthorship W2015227598A5007489715 @default.
- W2015227598 hasAuthorship W2015227598A5033436256 @default.
- W2015227598 hasAuthorship W2015227598A5056176641 @default.
- W2015227598 hasAuthorship W2015227598A5060325672 @default.
- W2015227598 hasAuthorship W2015227598A5086708669 @default.
- W2015227598 hasConcept C154317977 @default.
- W2015227598 hasConcept C178790620 @default.
- W2015227598 hasConcept C181199279 @default.
- W2015227598 hasConcept C185592680 @default.
- W2015227598 hasConcept C202751555 @default.
- W2015227598 hasConcept C203014093 @default.
- W2015227598 hasConcept C2776008721 @default.
- W2015227598 hasConcept C2776914184 @default.
- W2015227598 hasConcept C2777477808 @default.
- W2015227598 hasConcept C2777622882 @default.
- W2015227598 hasConcept C2778754761 @default.