FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015228508> ?p ?o ?g. }

• W2015228508 endingPage "799" @default.
• W2015228508 startingPage "788" @default.
• W2015228508 abstract "A431 cells escape EGF-induced apoptosis by forming cell aggregates. We show that these clusters migrate and merge with neighboring ones, resulting in larger structures composed of a multilayer central (3D) population surrounded by a cell monolayer (2D). We found that after 48 hr of 10 nM EGF treatment, 3D structure formation correlates with alpha2beta1 integrin upregulation. Blockade of alpha2 integrin impairs 3D structure formation. We studied the involvement of reactive oxygen species (ROS) in this process. We show that A431 cells express the NADPH oxidase catalytic subunits Nox1. EGF-induced dose-dependent ROS production was inhibited by the NADPH oxidase inhibitor, diphenylene iodonium (DPI), in these cells while rotenone was ineffective. Inhibition of ROS level in A431 cells with DPI or ebselen (glutathione peroxydase mimic) as well as P38 MAP kinase inhibition by SB203580 decreases alpha2 integrin subunit expression and induces a shift to 3D versus 2D populations. Cell cycle analysis of 2D cells shows that DPI, ebselen and SB203580 decrease the number of cells in S/G2 phase without affecting the cell number in mitosis phase. On the contrary, for 3D cells, these treatments increased the proportion of cells in mitosis without modification of the cell number in S/G2 phase. For both populations, apoptosis was increased by DPI and ebselen. Resistance of cell aggregates by paclitaxel to cell death is usually described. We show that DPI abolishes paclitaxel resistance of 3D cell aggregates. We observed a greater than additive effect between paclitaxel and DPI resulting in an increased proportion of cells in S/G2 phase for 3D populations. These results suggested that the ROS-P38 MAP kinase-alpha2beta1 integrin pathway was implicated in the A431 survival process by modulating the balance between 2D/3D cells." @default.
• W2015228508 created "2016-06-24" @default.
• W2015228508 creator A5003184255 @default.
• W2015228508 creator A5003846685 @default.
• W2015228508 creator A5047343134 @default.
• W2015228508 creator A5074530239 @default.
• W2015228508 creator A5077288730 @default.
• W2015228508 creator A5079926225 @default.
• W2015228508 date "2004-05-26" @default.
• W2015228508 modified "2023-10-06" @default.
• W2015228508 title "Monolayerversus aggregate balance in survival process for EGF-induced apoptosis in A431 carcinoma cells: Implication of ROS-P38 MAPK-integrin ?2?1 pathway" @default.
• W2015228508 cites W1569638668 @default.
• W2015228508 cites W1638074023 @default.
• W2015228508 cites W1760891502 @default.
• W2015228508 cites W1971915141 @default.
• W2015228508 cites W1980763627 @default.
• W2015228508 cites W1980849916 @default.
• W2015228508 cites W1988479585 @default.
• W2015228508 cites W1990484506 @default.
• W2015228508 cites W1992628345 @default.
• W2015228508 cites W1995819749 @default.
• W2015228508 cites W1999500740 @default.
• W2015228508 cites W2003523718 @default.
• W2015228508 cites W2011113156 @default.
• W2015228508 cites W2014128175 @default.
• W2015228508 cites W2016008185 @default.
• W2015228508 cites W2018232682 @default.
• W2015228508 cites W2019691808 @default.
• W2015228508 cites W2020475637 @default.
• W2015228508 cites W2025198517 @default.
• W2015228508 cites W2032359283 @default.
• W2015228508 cites W2036172228 @default.
• W2015228508 cites W2036228484 @default.
• W2015228508 cites W2038816853 @default.
• W2015228508 cites W2047083378 @default.
• W2015228508 cites W2048569323 @default.
• W2015228508 cites W2048758017 @default.
• W2015228508 cites W2048997359 @default.
• W2015228508 cites W2049207291 @default.
• W2015228508 cites W2049482115 @default.
• W2015228508 cites W2051554687 @default.
• W2015228508 cites W2052943534 @default.
• W2015228508 cites W2060630008 @default.
• W2015228508 cites W2061323485 @default.
• W2015228508 cites W2063434802 @default.
• W2015228508 cites W2064829245 @default.
• W2015228508 cites W2073557222 @default.
• W2015228508 cites W2079275926 @default.
• W2015228508 cites W2080233238 @default.
• W2015228508 cites W2082176660 @default.
• W2015228508 cites W2084046697 @default.
• W2015228508 cites W2091576322 @default.
• W2015228508 cites W2096931514 @default.
• W2015228508 cites W2101537600 @default.
• W2015228508 cites W2101745219 @default.
• W2015228508 cites W2104251051 @default.
• W2015228508 cites W2106929134 @default.
• W2015228508 cites W2107436374 @default.
• W2015228508 cites W2107902151 @default.
• W2015228508 cites W2109594092 @default.
• W2015228508 cites W2109662937 @default.
• W2015228508 cites W2110048188 @default.
• W2015228508 cites W2110676635 @default.
• W2015228508 cites W2128929514 @default.
• W2015228508 cites W2137046569 @default.
• W2015228508 cites W2142088831 @default.
• W2015228508 cites W2149870206 @default.
• W2015228508 cites W2163856919 @default.
• W2015228508 cites W2168856134 @default.
• W2015228508 cites W2169816639 @default.
• W2015228508 cites W2330980944 @default.
• W2015228508 cites W2400588389 @default.
• W2015228508 cites W4249931481 @default.
• W2015228508 doi "https://doi.org/10.1002/ijc.20198" @default.
• W2015228508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15170659" @default.
• W2015228508 hasPublicationYear "2004" @default.
• W2015228508 type Work @default.
• W2015228508 sameAs 2015228508 @default.
• W2015228508 citedByCount "23" @default.
• W2015228508 countsByYear W20152285082013 @default.
• W2015228508 countsByYear W20152285082015 @default.
• W2015228508 countsByYear W20152285082016 @default.
• W2015228508 countsByYear W20152285082019 @default.
• W2015228508 countsByYear W20152285082022 @default.
• W2015228508 countsByYear W20152285082023 @default.
• W2015228508 crossrefType "journal-article" @default.
• W2015228508 hasAuthorship W2015228508A5003184255 @default.
• W2015228508 hasAuthorship W2015228508A5003846685 @default.
• W2015228508 hasAuthorship W2015228508A5047343134 @default.
• W2015228508 hasAuthorship W2015228508A5074530239 @default.
• W2015228508 hasAuthorship W2015228508A5077288730 @default.
• W2015228508 hasAuthorship W2015228508A5079926225 @default.
• W2015228508 hasBestOaLocation W20152285081 @default.
• W2015228508 hasConcept C1491633281 @default.
• W2015228508 hasConcept C153911025 @default.
• W2015228508 hasConcept C184235292 @default.
• W2015228508 hasConcept C185592680 @default.
• W2015228508 hasConcept C190283241 @default.

• next