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• W2015228653 abstract "Introduction: Mini-tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles such as impaired swallowing and polypharmacy therapy, and also offering some therapeutic benefits such as dose flexibility and combined release patterns. Mini-tablets are a promising patient-friendly drug delivery system.Areas covered: Mini-tablets are tablets with a diameter ≤ 3 mm produced on conventional tablet presses equipped with multiple tooling. Mini-tablet production is similar to the production of standard tablets but requires excellent powder flow due to the small dies, exact control of process parameters and special caution during tablet press assembly in order to avoid tool damage. Mini-tablets (coated or uncoated and single- or multiple-unit systems) are mainly developed as patient-friendly systems for pediatric and geriatric patients and also for personalized medicine because they offer improved swallowing and flexible dosing, combining various release kinetics, doses and active compounds in only one system. Mini-tablets may also be successfully used as multiple-unit modified release systems (extended release, delayed-colon release, pulsatile and bi-modal release and gastroretentive systems) providing improved drug bioavailability compared with single-unit systems.Expert opinion: Mini-tablets used as single- or multiple-unit oral dosage forms have enormous potential as a patient-friendly drug delivery system for targeted populations, providing improved swallowing, flexible dosing and a combination of different release patterns and/or different active compounds (decreasing dosing frequency and/or polypharmacy therapy problems). In terms of complete expression of the benefits of mini-tablets over other oral dosage forms on the market, further investigation in formulation possibilities and development of suitable dosing devices is of essential importance." @default.
• W2015228653 created "2016-06-24" @default.
• W2015228653 creator A5009619456 @default.
• W2015228653 creator A5020854797 @default.
• W2015228653 creator A5024941898 @default.
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• W2015228653 date "2014-09-09" @default.
• W2015228653 modified "2023-10-12" @default.
• W2015228653 title "Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups" @default.
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• W2015228653 doi "https://doi.org/10.1517/17425247.2014.951633" @default.
• W2015228653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25200881" @default.
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