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- W2015230607 abstract "Epstein–Barr virus (EBV)-associated lymphoproliferations represent life-threatening complications of hematopoietic stem cell transplantation. In the last decade, immunological therapeutic strategies that allow us to selectively abrogate the origin of lymphoproliferation, namely B-cell compartment or EBV antigen-expressing tumor cells, have significantly reduced treatment-related toxicity while maintaining equal or superior efficacy. A further implementation is the possibility of preventing disease occurrence by delivering immunotherapy in the presymptomatic phase, on the basis of EBV-DNA blood levels. Despite the excellent results, T-cell therapy with EBV-specific cytotoxic T-lymphocytes has but a marginal role in the treatment of these forms. Promising implementations are underway, including logistic solutions to extend T-cell therapy beyond academic centers, delineation of strategies aimed at simplifying/shortening production and targeting immune evasion mechanisms exerted by tumor cells." @default.
- W2015230607 created "2016-06-24" @default.
- W2015230607 creator A5050104358 @default.
- W2015230607 creator A5050682361 @default.
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- W2015230607 date "2010-10-01" @default.
- W2015230607 modified "2023-09-27" @default.
- W2015230607 title "Immunotherapy against EBV-lymphoma in recipients of HSCT" @default.
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- W2015230607 doi "https://doi.org/10.1586/ehm.10.56" @default.
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