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- W2015231189 abstract "Analogs of the psychotropic phenothiazines were synthesized and examined as antitubercular agents against Mycobacterium tuberculosis H37Rv. The compounds were subsequently counter-screened for binding to the dopaminergic-receptor subtypes D1, D2, D3 and the serotonergic-receptor subtypes 5-HT(1A), 5-HT(2A), and 5-HT(2C). The most active compounds showed MICs from 2 to 4 microg/mL and had overall reduced binding to the dopamine and serotonin receptors compared to chlorpromazine and trifluoperazine." @default.
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- W2015231189 date "2007-06-01" @default.
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- W2015231189 title "Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors" @default.
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- W2015231189 doi "https://doi.org/10.1016/j.bmcl.2007.03.064" @default.
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