FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015231657> ?p ?o ?g. }

• W2015231657 endingPage "128" @default.
• W2015231657 startingPage "121" @default.
• W2015231657 abstract "Whether propofol produces a pleasant affective state remains unclear from clinical studies. In the current study, the effect on affective state of subanesthetic and anesthetic doses of propofol was assessed at a preclinical level with rats in a place conditioning paradigm. Propofol was compared with methohexital.In the place conditioning paradigm, propofol-induced effect was repeatedly paired with one of two distinguishable compartments of the apparatus, whereas the vehicle-induced effect was repeatedly paired with the other compartment. During a subsequent free-choice test, a preference for the drug-paired compartment over the vehicle-paired compartment would be indicative of pleasant state induced by the drug. For all experiments, the conditioning session lasted 8 days and consisted of four pairings of the drug with one compartment and four pairings of the equivalent volume of vehicle with the other compartment. In experiment 1A, four groups of rats were designated according to the dose of propofol that they received intraperitoneally: 0,30,60, or 90 mg/kg. In experiment 1B, the same procedure was used with subanesthetic doses of intraperitoneal methohexital: 0,10,20, or 30 mg/kg. In experiment 2, the rats were conditioned during the recovery period from short-term anesthesia. For one group, anesthesia was induced by propofol (100 mg/kg) whereas for the other group, anesthesia was induced by an equivalent anesthetic dose of methohexital (40 mg/kg).In experiment 1A, the 30-mg/kg, 60-mg/kg, and 90-mg/kg groups showed a place preference for the drug-paired compartment, but only the group conditioned with 60 mg/kg propofol significantly differed from the 0-mg/kg group. In experiment 1B, the groups conditioned with methohexital showed no place preference for the drug-paired compartment. In experiment 2, the rats showed a place preference for the compartment in which they recovered from propofol-induced anesthesia but no place preference for the compartment in which they recovered from methohexital-induced anesthesia.Propofol, but not methohexital, induced a pleasant affective state in rats at subanesthetic doses as well as during recovery from an anesthetic dose." @default.
• W2015231657 created "2016-06-24" @default.
• W2015231657 creator A5002336646 @default.
• W2015231657 creator A5013460067 @default.
• W2015231657 creator A5019572753 @default.
• W2015231657 creator A5078532293 @default.
• W2015231657 date "1996-07-01" @default.
• W2015231657 modified "2023-10-14" @default.
• W2015231657 title "Effect of Propofol on Affective State as Assessed by Place Conditioning Paradigm in Rats" @default.
• W2015231657 cites W1968554367 @default.
• W2015231657 cites W1970407112 @default.
• W2015231657 cites W1987171063 @default.
• W2015231657 cites W1993497759 @default.
• W2015231657 cites W1994985557 @default.
• W2015231657 cites W1995800815 @default.
• W2015231657 cites W2005101125 @default.
• W2015231657 cites W2013008572 @default.
• W2015231657 cites W2017491485 @default.
• W2015231657 cites W2025488722 @default.
• W2015231657 cites W2045995579 @default.
• W2015231657 cites W2048612001 @default.
• W2015231657 cites W2051932502 @default.
• W2015231657 cites W2055023799 @default.
• W2015231657 cites W2071681802 @default.
• W2015231657 cites W2074769594 @default.
• W2015231657 cites W2079751829 @default.
• W2015231657 cites W2082144170 @default.
• W2015231657 cites W2083730032 @default.
• W2015231657 cites W2088757883 @default.
• W2015231657 cites W2106862702 @default.
• W2015231657 cites W2164829261 @default.
• W2015231657 cites W2170810822 @default.
• W2015231657 doi "https://doi.org/10.1097/00000542-199607000-00017" @default.
• W2015231657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8694357" @default.
• W2015231657 hasPublicationYear "1996" @default.
• W2015231657 type Work @default.
• W2015231657 sameAs 2015231657 @default.
• W2015231657 citedByCount "55" @default.
• W2015231657 countsByYear W20152316572012 @default.
• W2015231657 countsByYear W20152316572013 @default.
• W2015231657 countsByYear W20152316572014 @default.
• W2015231657 countsByYear W20152316572015 @default.
• W2015231657 countsByYear W20152316572016 @default.
• W2015231657 countsByYear W20152316572017 @default.
• W2015231657 countsByYear W20152316572018 @default.
• W2015231657 countsByYear W20152316572020 @default.
• W2015231657 countsByYear W20152316572021 @default.
• W2015231657 countsByYear W20152316572022 @default.
• W2015231657 crossrefType "journal-article" @default.
• W2015231657 hasAuthorship W2015231657A5002336646 @default.
• W2015231657 hasAuthorship W2015231657A5013460067 @default.
• W2015231657 hasAuthorship W2015231657A5019572753 @default.
• W2015231657 hasAuthorship W2015231657A5078532293 @default.
• W2015231657 hasBestOaLocation W20152316571 @default.
• W2015231657 hasConcept C105795698 @default.
• W2015231657 hasConcept C111368507 @default.
• W2015231657 hasConcept C127313418 @default.
• W2015231657 hasConcept C203635412 @default.
• W2015231657 hasConcept C2776277131 @default.
• W2015231657 hasConcept C2776814716 @default.
• W2015231657 hasConcept C2777260365 @default.
• W2015231657 hasConcept C2777389121 @default.
• W2015231657 hasConcept C2778162923 @default.
• W2015231657 hasConcept C33923547 @default.
• W2015231657 hasConcept C35124327 @default.
• W2015231657 hasConcept C42219234 @default.
• W2015231657 hasConcept C45262634 @default.
• W2015231657 hasConcept C71924100 @default.
• W2015231657 hasConcept C98274493 @default.
• W2015231657 hasConceptScore W2015231657C105795698 @default.
• W2015231657 hasConceptScore W2015231657C111368507 @default.
• W2015231657 hasConceptScore W2015231657C127313418 @default.
• W2015231657 hasConceptScore W2015231657C203635412 @default.
• W2015231657 hasConceptScore W2015231657C2776277131 @default.
• W2015231657 hasConceptScore W2015231657C2776814716 @default.
• W2015231657 hasConceptScore W2015231657C2777260365 @default.
• W2015231657 hasConceptScore W2015231657C2777389121 @default.
• W2015231657 hasConceptScore W2015231657C2778162923 @default.
• W2015231657 hasConceptScore W2015231657C33923547 @default.
• W2015231657 hasConceptScore W2015231657C35124327 @default.
• W2015231657 hasConceptScore W2015231657C42219234 @default.
• W2015231657 hasConceptScore W2015231657C45262634 @default.
• W2015231657 hasConceptScore W2015231657C71924100 @default.
• W2015231657 hasConceptScore W2015231657C98274493 @default.
• W2015231657 hasIssue "1" @default.
• W2015231657 hasLocation W20152316571 @default.
• W2015231657 hasLocation W20152316572 @default.
• W2015231657 hasOpenAccess W2015231657 @default.
• W2015231657 hasPrimaryLocation W20152316571 @default.
• W2015231657 hasRelatedWork W153907945 @default.
• W2015231657 hasRelatedWork W1692262809 @default.
• W2015231657 hasRelatedWork W1968490156 @default.
• W2015231657 hasRelatedWork W2015231657 @default.
• W2015231657 hasRelatedWork W2025085996 @default.
• W2015231657 hasRelatedWork W2045805173 @default.
• W2015231657 hasRelatedWork W2066019222 @default.
• W2015231657 hasRelatedWork W2358288014 @default.
• W2015231657 hasRelatedWork W2373652031 @default.

• next