FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015236906> ?p ?o ?g. }

• W2015236906 endingPage "e7153" @default.
• W2015236906 startingPage "e7153" @default.
• W2015236906 abstract "Glutamate (Glu) and gamma-aminobutyric acid (GABA) transporters play important roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly by glial transporters. In contrast, GABA is mainly taken up by neurons. However, the glial GABA transporter subtypes share their localization with the Glu transporters and their expression is confined to the same subpopulation of astrocytes, raising the possibility of cooperation between Glu and GABA transport processes.Here we used diverse biological models both in vitro and in vivo to explore the interplay between these processes. We found that removal of Glu by astrocytic transporters triggers an elevation in the extracellular level of GABA. This coupling between excitatory and inhibitory signaling was found to be independent of Glu receptor-mediated depolarization, external presence of Ca(2+) and glutamate decarboxylase activity. It was abolished in the presence of non-transportable blockers of glial Glu or GABA transporters, suggesting that the concerted action of these transporters underlies the process.Our results suggest that activation of Glu transporters results in GABA release through reversal of glial GABA transporters. This transporter-mediated interplay represents a direct link between inhibitory and excitatory neurotransmission and may function as a negative feedback combating intense excitation in pathological conditions such as epilepsy or ischemia." @default.
• W2015236906 created "2016-06-24" @default.
• W2015236906 creator A5007370576 @default.
• W2015236906 creator A5011891960 @default.
• W2015236906 creator A5024989059 @default.
• W2015236906 creator A5028829540 @default.
• W2015236906 creator A5044402680 @default.
• W2015236906 creator A5060217047 @default.
• W2015236906 creator A5060434388 @default.
• W2015236906 creator A5060835610 @default.
• W2015236906 creator A5071612792 @default.
• W2015236906 creator A5077988654 @default.
• W2015236906 creator A5084703314 @default.
• W2015236906 creator A5088625711 @default.
• W2015236906 date "2009-09-24" @default.
• W2015236906 modified "2023-10-17" @default.
• W2015236906 title "Glutamate Uptake Triggers Transporter-Mediated GABA Release from Astrocytes" @default.
• W2015236906 cites W1519351707 @default.
• W2015236906 cites W1679634005 @default.
• W2015236906 cites W1828807460 @default.
• W2015236906 cites W1968283415 @default.
• W2015236906 cites W1972023055 @default.
• W2015236906 cites W1972161610 @default.
• W2015236906 cites W1977265431 @default.
• W2015236906 cites W1977291110 @default.
• W2015236906 cites W1983494151 @default.
• W2015236906 cites W1990969488 @default.
• W2015236906 cites W1997964026 @default.
• W2015236906 cites W2001422973 @default.
• W2015236906 cites W2003801881 @default.
• W2015236906 cites W2010363113 @default.
• W2015236906 cites W2019176706 @default.
• W2015236906 cites W2020487122 @default.
• W2015236906 cites W2022185246 @default.
• W2015236906 cites W2029839239 @default.
• W2015236906 cites W2035605035 @default.
• W2015236906 cites W2044475482 @default.
• W2015236906 cites W2049384506 @default.
• W2015236906 cites W2053739364 @default.
• W2015236906 cites W2058107876 @default.
• W2015236906 cites W2058766494 @default.
• W2015236906 cites W2062536533 @default.
• W2015236906 cites W2063792905 @default.
• W2015236906 cites W2064454723 @default.
• W2015236906 cites W2065116247 @default.
• W2015236906 cites W2066264229 @default.
• W2015236906 cites W2066775856 @default.
• W2015236906 cites W2078569891 @default.
• W2015236906 cites W2081465656 @default.
• W2015236906 cites W2082436201 @default.
• W2015236906 cites W2082450845 @default.
• W2015236906 cites W2087356150 @default.
• W2015236906 cites W2088607053 @default.
• W2015236906 cites W2092305939 @default.
• W2015236906 cites W2092479894 @default.
• W2015236906 cites W2094988806 @default.
• W2015236906 cites W2103064125 @default.
• W2015236906 cites W2109942506 @default.
• W2015236906 cites W2114745427 @default.
• W2015236906 cites W2115027782 @default.
• W2015236906 cites W2126033464 @default.
• W2015236906 cites W2132949150 @default.
• W2015236906 cites W2133739832 @default.
• W2015236906 cites W2139230578 @default.
• W2015236906 cites W2153999860 @default.
• W2015236906 cites W2162637085 @default.
• W2015236906 cites W2166354096 @default.
• W2015236906 cites W2170867393 @default.
• W2015236906 cites W2247356410 @default.
• W2015236906 cites W4210979710 @default.
• W2015236906 doi "https://doi.org/10.1371/journal.pone.0007153" @default.
• W2015236906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2744931" @default.
• W2015236906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19777062" @default.
• W2015236906 hasPublicationYear "2009" @default.
• W2015236906 type Work @default.
• W2015236906 sameAs 2015236906 @default.
• W2015236906 citedByCount "107" @default.
• W2015236906 countsByYear W20152369062012 @default.
• W2015236906 countsByYear W20152369062013 @default.
• W2015236906 countsByYear W20152369062014 @default.
• W2015236906 countsByYear W20152369062015 @default.
• W2015236906 countsByYear W20152369062016 @default.
• W2015236906 countsByYear W20152369062017 @default.
• W2015236906 countsByYear W20152369062018 @default.
• W2015236906 countsByYear W20152369062019 @default.
• W2015236906 countsByYear W20152369062020 @default.
• W2015236906 countsByYear W20152369062021 @default.
• W2015236906 countsByYear W20152369062022 @default.
• W2015236906 countsByYear W20152369062023 @default.
• W2015236906 crossrefType "journal-article" @default.
• W2015236906 hasAuthorship W2015236906A5007370576 @default.
• W2015236906 hasAuthorship W2015236906A5011891960 @default.
• W2015236906 hasAuthorship W2015236906A5024989059 @default.
• W2015236906 hasAuthorship W2015236906A5028829540 @default.
• W2015236906 hasAuthorship W2015236906A5044402680 @default.
• W2015236906 hasAuthorship W2015236906A5060217047 @default.
• W2015236906 hasAuthorship W2015236906A5060434388 @default.
• W2015236906 hasAuthorship W2015236906A5060835610 @default.

• next