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- W2015238619 abstract "The effect of sodium DL-lactate administration on insulin release in anesthetized dogs has been studied. Eleven mongrel dogs were infused with sodium DL-lactate for 20 min at the rate of 20 mg/kg · min. Lactate infusion produced simultaneous increases in blood glucose and plasma insulin levels in the pancreatico-duodenal vein. To determine whether lactate stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from pancreatic B-cells, even in the absence of a measurable change in blood glucose. Diazoxide, when infused in six dogs, blocked lactate-induced insulin secretion. These findings indicate that lactate, as do other circulating energy fuels, may play a role in the physiologic control of insulin secretion." @default.
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- W2015238619 date "1980-01-01" @default.
- W2015238619 modified "2023-09-27" @default.
- W2015238619 title "Effects of Sodium DL-Lactate on Insulin Secretion in Anesthetized Dogs" @default.
- W2015238619 doi "https://doi.org/10.2337/diab.29.1.33" @default.
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