FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015239439> ?p ?o ?g. }

• W2015239439 endingPage "541" @default.
• W2015239439 startingPage "534" @default.
• W2015239439 abstract "To investigate whether low doses of exogenous interferon (IFN)-γ attenuate airway inflammation, and the underlying mechanisms, in asthma. C57BL/6 mice (n=42), after intraperitoneal ovalbumin (OVA) sensitization on day 0 and day 12, were challenged with OVA aerosol for 6 consecutive days. Different doses of IFN-γ were then administered intraperitoneally 5 min before each inhalation during OVA challenge. Airway hyperresponsiveness, airway inflammatory cells, cytokine profiles, and Fas/FasL expression on CD4(+) T cells were evaluated in an asthma model. The effect of various IFN-γ doses on Fas/FasL expression and CD4(+) T cell apoptosis were assessed in vitro. We demonstrated that low doses of IFN-γ reduced pulmonary infiltration of inflammatory cells, Th2 cytokine production, and goblet cells hyperplasia (P<0.05), while high doses of endogenous IFN-γ had almost no effect. We also found that low doses of IFN-γ relocated Fas/FasL to the CD4(+) T cell surface in the asthma model (P<0.05) and increased FasL-induced apoptosis in vitro (P<0.05). Furthermore, treatment with MFL-3, an anti-FasL antibody, partially abolished the anti- inflammatory properties of IFN-γ in the airway rather than affecting the Th1/Th2 balance. This research has revealed an alternative mechanism in asthma that involves low doses of IFN-γ, which attenuate airway inflammation through enhancing Fas/FasL-induced CD4(+) T cell apoptosis." @default.
• W2015239439 created "2016-06-24" @default.
• W2015239439 creator A5001172148 @default.
• W2015239439 creator A5020242338 @default.
• W2015239439 creator A5027848107 @default.
• W2015239439 creator A5046266040 @default.
• W2015239439 creator A5052132950 @default.
• W2015239439 date "2012-11-01" @default.
• W2015239439 modified "2023-10-14" @default.
• W2015239439 title "Low Doses of Exogenous Interferon-γ Attenuated Airway Inflammation Through Enhancing Fas/FasL-Induced CD4⁺T Cell Apoptosis in a Mouse Asthma Model" @default.
• W2015239439 cites W1518633297 @default.
• W2015239439 cites W1523689878 @default.
• W2015239439 cites W1750011177 @default.
• W2015239439 cites W1804142007 @default.
• W2015239439 cites W1854728040 @default.
• W2015239439 cites W1969594061 @default.
• W2015239439 cites W1976536469 @default.
• W2015239439 cites W2003635816 @default.
• W2015239439 cites W2011754426 @default.
• W2015239439 cites W2042511584 @default.
• W2015239439 cites W2063630313 @default.
• W2015239439 cites W2082293109 @default.
• W2015239439 cites W2090644434 @default.
• W2015239439 cites W2090831287 @default.
• W2015239439 cites W2094590708 @default.
• W2015239439 cites W2105360761 @default.
• W2015239439 cites W2127616716 @default.
• W2015239439 cites W2130183546 @default.
• W2015239439 cites W2130794319 @default.
• W2015239439 cites W2135805017 @default.
• W2015239439 cites W2142623432 @default.
• W2015239439 cites W2156600482 @default.
• W2015239439 cites W2164692566 @default.
• W2015239439 cites W2169955081 @default.
• W2015239439 doi "https://doi.org/10.1089/jir.2012.0016" @default.
• W2015239439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3493050" @default.
• W2015239439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22994871" @default.
• W2015239439 hasPublicationYear "2012" @default.
• W2015239439 type Work @default.
• W2015239439 sameAs 2015239439 @default.
• W2015239439 citedByCount "7" @default.
• W2015239439 countsByYear W20152394392014 @default.
• W2015239439 countsByYear W20152394392017 @default.
• W2015239439 countsByYear W20152394392018 @default.
• W2015239439 countsByYear W20152394392020 @default.
• W2015239439 countsByYear W20152394392023 @default.
• W2015239439 crossrefType "journal-article" @default.
• W2015239439 hasAuthorship W2015239439A5001172148 @default.
• W2015239439 hasAuthorship W2015239439A5020242338 @default.
• W2015239439 hasAuthorship W2015239439A5027848107 @default.
• W2015239439 hasAuthorship W2015239439A5046266040 @default.
• W2015239439 hasAuthorship W2015239439A5052132950 @default.
• W2015239439 hasBestOaLocation W20152394392 @default.
• W2015239439 hasConcept C185592680 @default.
• W2015239439 hasConcept C190283241 @default.
• W2015239439 hasConcept C203014093 @default.
• W2015239439 hasConcept C2776178377 @default.
• W2015239439 hasConcept C2776914184 @default.
• W2015239439 hasConcept C2776946954 @default.
• W2015239439 hasConcept C2778690821 @default.
• W2015239439 hasConcept C2780841837 @default.
• W2015239439 hasConcept C31573885 @default.
• W2015239439 hasConcept C55493867 @default.
• W2015239439 hasConcept C66008609 @default.
• W2015239439 hasConcept C71924100 @default.
• W2015239439 hasConcept C8891405 @default.
• W2015239439 hasConceptScore W2015239439C185592680 @default.
• W2015239439 hasConceptScore W2015239439C190283241 @default.
• W2015239439 hasConceptScore W2015239439C203014093 @default.
• W2015239439 hasConceptScore W2015239439C2776178377 @default.
• W2015239439 hasConceptScore W2015239439C2776914184 @default.
• W2015239439 hasConceptScore W2015239439C2776946954 @default.
• W2015239439 hasConceptScore W2015239439C2778690821 @default.
• W2015239439 hasConceptScore W2015239439C2780841837 @default.
• W2015239439 hasConceptScore W2015239439C31573885 @default.
• W2015239439 hasConceptScore W2015239439C55493867 @default.
• W2015239439 hasConceptScore W2015239439C66008609 @default.
• W2015239439 hasConceptScore W2015239439C71924100 @default.
• W2015239439 hasConceptScore W2015239439C8891405 @default.
• W2015239439 hasIssue "11" @default.
• W2015239439 hasLocation W20152394391 @default.
• W2015239439 hasLocation W20152394392 @default.
• W2015239439 hasLocation W20152394393 @default.
• W2015239439 hasLocation W20152394394 @default.
• W2015239439 hasOpenAccess W2015239439 @default.
• W2015239439 hasPrimaryLocation W20152394391 @default.
• W2015239439 hasRelatedWork W1964674919 @default.
• W2015239439 hasRelatedWork W1968234338 @default.
• W2015239439 hasRelatedWork W2002936791 @default.
• W2015239439 hasRelatedWork W2036175167 @default.
• W2015239439 hasRelatedWork W2079537492 @default.
• W2015239439 hasRelatedWork W2286986362 @default.
• W2015239439 hasRelatedWork W2412960471 @default.
• W2015239439 hasRelatedWork W263784416 @default.
• W2015239439 hasRelatedWork W284386456 @default.
• W2015239439 hasRelatedWork W3118313920 @default.
• W2015239439 hasVolume "32" @default.
• W2015239439 isParatext "false" @default.

• next