FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015241507> ?p ?o ?g. }

• W2015241507 endingPage "2735" @default.
• W2015241507 startingPage "2735" @default.
• W2015241507 abstract "A hyperbranched cationic polysaccharide derivative-mediated small interfering (si)RNA interference strategy was proposed to inhibit nuclear transcription factor-kappa B (NF-κB) activation in human retinal pigment epithelial (hRPE) cells for the gene therapy of diabetic retinopathy. Two hyperbranched cationic polysaccharide derivatives containing the same amount of cationic residues, but with different branching structures and molecular weights, including 3-(dimethylamino)-1-propylamine-conjugated glycogen (DMAPA-Glyp) and amylopectin (DMAPA-Amp) derivatives, were developed for the efficient delivery of NF-κB siRNA into hRPE cells. The DMAPA-Glyp derivative showed lower toxicity against hRPE cells. Furthermore, the DMAPA-Glyp derivative more readily condensed siRNA and then formed the nanoparticles attributed to its higher branching architecture when compared to the DMAPA-Amp derivative. Both DMAPA-Glyp/siRNA and DMAPA-Amp/siRNA nanoparticles were able to protect siRNA from degradation by nuclease in 25% fetal bovine serum. The particle sizes of the DMAPA-Glyp/siRNA nanoparticles (70-120 nm) were smaller than those of the DMAPA-Amp/siRNA nanoparticles (130-180 nm) due to the higher branching architecture and lower molecular weight of the DMAPA-Glyp derivative. In addition, the zeta potentials of the DMAPA-Glyp/siRNA nanoparticles were higher than those of the DMAPA-Glyp/siRNA nanoparticles. As a result, siRNA was much more efficiently transferred into hRPE cells using the DMAPA-Glyp/siRNA nanoparticles rather than the DMAPA-Amp/siRNA nanoparticles. This led to significantly high levels of suppression on the expression levels of NF-κB p65 messenger RNA and protein in the cells transfected with DMAPA-Glyp/siRNA nanoparticles. This work provides a potential approach to promote hyperbranched polysaccharide derivatives as nonviral siRNA vectors for the inhibition of NF-κB activation in hRPE cells." @default.
• W2015241507 created "2016-06-24" @default.
• W2015241507 creator A5003459470 @default.
• W2015241507 creator A5027425091 @default.
• W2015241507 creator A5030155062 @default.
• W2015241507 creator A5054844187 @default.
• W2015241507 creator A5054919439 @default.
• W2015241507 creator A5059905480 @default.
• W2015241507 creator A5090730101 @default.
• W2015241507 date "2015-04-01" @default.
• W2015241507 modified "2023-10-16" @default.
• W2015241507 title "Efficient delivery of NF-&kappa;B siRNA to human retinal pigment epithelial cells with hyperbranched cationic polysaccharide derivative-based nanoparticles" @default.
• W2015241507 cites W170658980 @default.
• W2015241507 cites W183134926 @default.
• W2015241507 cites W1965563034 @default.
• W2015241507 cites W1969490239 @default.
• W2015241507 cites W1973838111 @default.
• W2015241507 cites W1984142967 @default.
• W2015241507 cites W1991553460 @default.
• W2015241507 cites W1998471162 @default.
• W2015241507 cites W1999230530 @default.
• W2015241507 cites W1999961827 @default.
• W2015241507 cites W2008028087 @default.
• W2015241507 cites W2008334802 @default.
• W2015241507 cites W2012770017 @default.
• W2015241507 cites W2013719423 @default.
• W2015241507 cites W2016054780 @default.
• W2015241507 cites W2028483247 @default.
• W2015241507 cites W2034593998 @default.
• W2015241507 cites W2037435504 @default.
• W2015241507 cites W2038197749 @default.
• W2015241507 cites W2045753004 @default.
• W2015241507 cites W2046796927 @default.
• W2015241507 cites W2064209115 @default.
• W2015241507 cites W2066868344 @default.
• W2015241507 cites W2077197007 @default.
• W2015241507 cites W2080587952 @default.
• W2015241507 cites W2081683581 @default.
• W2015241507 cites W2092028723 @default.
• W2015241507 cites W2095426581 @default.
• W2015241507 cites W2096619102 @default.
• W2015241507 cites W2103058523 @default.
• W2015241507 cites W2167680304 @default.
• W2015241507 cites W2329020551 @default.
• W2015241507 cites W2419175081 @default.
• W2015241507 doi "https://doi.org/10.2147/ijn.s75188" @default.
• W2015241507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4396640" @default.
• W2015241507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25897219" @default.
• W2015241507 hasPublicationYear "2015" @default.
• W2015241507 type Work @default.
• W2015241507 sameAs 2015241507 @default.
• W2015241507 citedByCount "8" @default.
• W2015241507 countsByYear W20152415072016 @default.
• W2015241507 countsByYear W20152415072020 @default.
• W2015241507 countsByYear W20152415072021 @default.
• W2015241507 countsByYear W20152415072022 @default.
• W2015241507 countsByYear W20152415072023 @default.
• W2015241507 crossrefType "journal-article" @default.
• W2015241507 hasAuthorship W2015241507A5003459470 @default.
• W2015241507 hasAuthorship W2015241507A5027425091 @default.
• W2015241507 hasAuthorship W2015241507A5030155062 @default.
• W2015241507 hasAuthorship W2015241507A5054844187 @default.
• W2015241507 hasAuthorship W2015241507A5054919439 @default.
• W2015241507 hasAuthorship W2015241507A5059905480 @default.
• W2015241507 hasAuthorship W2015241507A5090730101 @default.
• W2015241507 hasBestOaLocation W20152415071 @default.
• W2015241507 hasConcept C100817775 @default.
• W2015241507 hasConcept C104317684 @default.
• W2015241507 hasConcept C12554922 @default.
• W2015241507 hasConcept C155672457 @default.
• W2015241507 hasConcept C171250308 @default.
• W2015241507 hasConcept C178790620 @default.
• W2015241507 hasConcept C183882617 @default.
• W2015241507 hasConcept C185592680 @default.
• W2015241507 hasConcept C192562407 @default.
• W2015241507 hasConcept C22615655 @default.
• W2015241507 hasConcept C54009773 @default.
• W2015241507 hasConcept C55493867 @default.
• W2015241507 hasConcept C67705224 @default.
• W2015241507 hasConcept C86181022 @default.
• W2015241507 hasConcept C86803240 @default.
• W2015241507 hasConceptScore W2015241507C100817775 @default.
• W2015241507 hasConceptScore W2015241507C104317684 @default.
• W2015241507 hasConceptScore W2015241507C12554922 @default.
• W2015241507 hasConceptScore W2015241507C155672457 @default.
• W2015241507 hasConceptScore W2015241507C171250308 @default.
• W2015241507 hasConceptScore W2015241507C178790620 @default.
• W2015241507 hasConceptScore W2015241507C183882617 @default.
• W2015241507 hasConceptScore W2015241507C185592680 @default.
• W2015241507 hasConceptScore W2015241507C192562407 @default.
• W2015241507 hasConceptScore W2015241507C22615655 @default.
• W2015241507 hasConceptScore W2015241507C54009773 @default.
• W2015241507 hasConceptScore W2015241507C55493867 @default.
• W2015241507 hasConceptScore W2015241507C67705224 @default.
• W2015241507 hasConceptScore W2015241507C86181022 @default.
• W2015241507 hasConceptScore W2015241507C86803240 @default.
• W2015241507 hasLocation W20152415071 @default.
• W2015241507 hasLocation W20152415072 @default.

• next