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- W2015243764 abstract "A new vaccine against the deadly malaria parasite Plasmodium falciparum primes the immune system to fight malaria. Researchers have developed a novel protein-like molecule based on the structure of merozoite surface protein 1 (MSP-1), which functions to anchor P. falciparum onto human red blood cells; once attached, the parasite invades the cell, multiplies and subsequently infects other cells. When the molecule was tested in monkeys, the antibodies that were produced recognized real MSP-1 proteins. The molecule is similar in structure to other vaccines that have been devised previously but exhibits a novel cyclic configuration, a property that might confer greater effectiveness than present malaria vaccines, which have thus far been disappointing. [Lioy, E. et al. (2001) Synthesis, biological and immunological properties of cyclic peptides from Plasmodium falciparum merozoite surface protein-1. Angew. Chem., Int. Ed. Engl. 40, 2631–2635] DC" @default.
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- W2015243764 date "2001-10-01" @default.
- W2015243764 modified "2023-09-26" @default.
- W2015243764 title "Malaria vaccine hope" @default.
- W2015243764 doi "https://doi.org/10.1016/s0165-6147(00)01874-5" @default.
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