Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015245896> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2015245896 endingPage "618" @default.
- W2015245896 startingPage "613" @default.
- W2015245896 abstract "Solanum aculeastrum. Dunal is a medicinal plant that has long been used to treat various cancers and many other conditions in the Eastern Cape Province of South Africa. In this study, two steroid glycosides were isolated from the berries of this plant, which were identified as tomatidine and solasodine by spectroscopic techniques. Effects on cell growth of these compounds were investigated with HeLa, MCF7, and HT29 cancer cell lines. The IC50 values confirmed that tomatidine and solasodine had the highest inhibitory effect on HeLa cells and the IC50 of the combined compounds was lower than the value for solasodine and unchanged from that of tomatidine. However, the IC50 values of the two compounds combined was also lower in HT29 and MCF7 cells than for the individual compounds. Both tomatidine and solasodine inhibited cell growth by blocking the cell cycle in the G0/G1 phase after 24-h exposure with an increase from 55.6% to 64.2% and 66.8%, respectively. Using annexin V–FITC/PI staining by flow cytometry, the compounds showed very low apoptotic indices." @default.
- W2015245896 created "2016-06-24" @default.
- W2015245896 creator A5006578673 @default.
- W2015245896 creator A5055232244 @default.
- W2015245896 creator A5063002895 @default.
- W2015245896 creator A5072425635 @default.
- W2015245896 date "2007-01-01" @default.
- W2015245896 modified "2023-10-10" @default.
- W2015245896 title "Anticancer Activity of Steroid Alkaloids Isolated from<i>Solanum aculeastrum</i>." @default.
- W2015245896 cites W122519560 @default.
- W2015245896 cites W1981519838 @default.
- W2015245896 cites W1984751575 @default.
- W2015245896 cites W1986612792 @default.
- W2015245896 cites W2007057690 @default.
- W2015245896 cites W2013380409 @default.
- W2015245896 cites W2014613601 @default.
- W2015245896 cites W2015753524 @default.
- W2015245896 cites W2017867735 @default.
- W2015245896 cites W2025272925 @default.
- W2015245896 cites W2026842951 @default.
- W2015245896 cites W2029310988 @default.
- W2015245896 cites W2032583299 @default.
- W2015245896 cites W2037502820 @default.
- W2015245896 cites W2052853635 @default.
- W2015245896 cites W2065375782 @default.
- W2015245896 cites W2069201303 @default.
- W2015245896 cites W2149598176 @default.
- W2015245896 doi "https://doi.org/10.1080/13880200701538690" @default.
- W2015245896 hasPublicationYear "2007" @default.
- W2015245896 type Work @default.
- W2015245896 sameAs 2015245896 @default.
- W2015245896 citedByCount "52" @default.
- W2015245896 countsByYear W20152458962012 @default.
- W2015245896 countsByYear W20152458962013 @default.
- W2015245896 countsByYear W20152458962014 @default.
- W2015245896 countsByYear W20152458962015 @default.
- W2015245896 countsByYear W20152458962016 @default.
- W2015245896 countsByYear W20152458962017 @default.
- W2015245896 countsByYear W20152458962018 @default.
- W2015245896 countsByYear W20152458962019 @default.
- W2015245896 countsByYear W20152458962020 @default.
- W2015245896 countsByYear W20152458962021 @default.
- W2015245896 countsByYear W20152458962022 @default.
- W2015245896 countsByYear W20152458962023 @default.
- W2015245896 crossrefType "journal-article" @default.
- W2015245896 hasAuthorship W2015245896A5006578673 @default.
- W2015245896 hasAuthorship W2015245896A5055232244 @default.
- W2015245896 hasAuthorship W2015245896A5063002895 @default.
- W2015245896 hasAuthorship W2015245896A5072425635 @default.
- W2015245896 hasBestOaLocation W20152458961 @default.
- W2015245896 hasConcept C1491633281 @default.
- W2015245896 hasConcept C185592680 @default.
- W2015245896 hasConcept C190283241 @default.
- W2015245896 hasConcept C202751555 @default.
- W2015245896 hasConcept C2777366897 @default.
- W2015245896 hasConcept C2777752497 @default.
- W2015245896 hasConcept C2777926911 @default.
- W2015245896 hasConcept C2781083041 @default.
- W2015245896 hasConcept C29537977 @default.
- W2015245896 hasConcept C55493867 @default.
- W2015245896 hasConcept C59822182 @default.
- W2015245896 hasConcept C62112901 @default.
- W2015245896 hasConcept C86803240 @default.
- W2015245896 hasConceptScore W2015245896C1491633281 @default.
- W2015245896 hasConceptScore W2015245896C185592680 @default.
- W2015245896 hasConceptScore W2015245896C190283241 @default.
- W2015245896 hasConceptScore W2015245896C202751555 @default.
- W2015245896 hasConceptScore W2015245896C2777366897 @default.
- W2015245896 hasConceptScore W2015245896C2777752497 @default.
- W2015245896 hasConceptScore W2015245896C2777926911 @default.
- W2015245896 hasConceptScore W2015245896C2781083041 @default.
- W2015245896 hasConceptScore W2015245896C29537977 @default.
- W2015245896 hasConceptScore W2015245896C55493867 @default.
- W2015245896 hasConceptScore W2015245896C59822182 @default.
- W2015245896 hasConceptScore W2015245896C62112901 @default.
- W2015245896 hasConceptScore W2015245896C86803240 @default.
- W2015245896 hasIssue "8" @default.
- W2015245896 hasLocation W20152458961 @default.
- W2015245896 hasOpenAccess W2015245896 @default.
- W2015245896 hasPrimaryLocation W20152458961 @default.
- W2015245896 hasRelatedWork W2354294515 @default.
- W2015245896 hasRelatedWork W2367968865 @default.
- W2015245896 hasRelatedWork W2368940306 @default.
- W2015245896 hasRelatedWork W2374614804 @default.
- W2015245896 hasRelatedWork W2376933360 @default.
- W2015245896 hasRelatedWork W2378203004 @default.
- W2015245896 hasRelatedWork W2384298454 @default.
- W2015245896 hasRelatedWork W2386797884 @default.
- W2015245896 hasRelatedWork W2392114150 @default.
- W2015245896 hasRelatedWork W2392484830 @default.
- W2015245896 hasVolume "45" @default.
- W2015245896 isParatext "false" @default.
- W2015245896 isRetracted "false" @default.
- W2015245896 magId "2015245896" @default.
- W2015245896 workType "article" @default.