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• W2015246311 abstract "Abstract The neuropathology of Alzheimer's disease (AD) is characterized by deposits of amyloid β (Aβ) peptides and neurofibrillary tangles, but also, among other aspects, by signs of a chronic inflammatory process. Epidemiological studies have shown that long‐term use of nonsteroidal antiinflammatory drugs (NSAIDs) reduces the risk of developing AD and delays its onset. The classic target of NSAIDs is the prevention of cyclooxygenase (COX) activation. The main mechanism of action of COXs is the synthesis of prostaglandins, some of which have potent inflammatory activity. The discovery of two isoforms of this enzyme, COX‐1 and COX‐2, and that the latter is inducible by inflammatory cytokines supported the hypothesis that its inhibition would result in a potent antiinflammatory effect and led to the rapid development of selective COX‐2 inhibitors, collectively called coxibs. Based on this rationale, some coxibs have been used in clinical trials for AD patients, but all the results obtained so far have been negative. Here, we review our knowledge in terms of COX‐2 in the central nervous system, COX‐2 and Aβ formation, and finally COX‐2 and AD pathogenesis to understand the reasons why these drugs have failed and whether there is any scientific support to keep them as therapeutic tools for this chronic disease. Ann Neurol 2006" @default.
• W2015246311 created "2016-06-24" @default.
• W2015246311 creator A5072202763 @default.
• W2015246311 creator A5091349162 @default.
• W2015246311 date "2006-01-09" @default.
• W2015246311 modified "2023-10-18" @default.
• W2015246311 title "Coxibs and Alzheimer's disease: Should they stay or should they go?" @default.
• W2015246311 cites W1516026106 @default.
• W2015246311 cites W1543238801 @default.
• W2015246311 cites W1551964881 @default.
• W2015246311 cites W1965417918 @default.
• W2015246311 cites W1966012148 @default.
• W2015246311 cites W1970055334 @default.
• W2015246311 cites W1970774262 @default.
• W2015246311 cites W1974450761 @default.
• W2015246311 cites W1977451682 @default.
• W2015246311 cites W1977813572 @default.
• W2015246311 cites W1981065845 @default.
• W2015246311 cites W1981554609 @default.
• W2015246311 cites W1982637771 @default.
• W2015246311 cites W1983479763 @default.
• W2015246311 cites W1985501273 @default.
• W2015246311 cites W1985844039 @default.
• W2015246311 cites W1986619381 @default.
• W2015246311 cites W1995198341 @default.
• W2015246311 cites W1996609121 @default.
• W2015246311 cites W2008424322 @default.
• W2015246311 cites W2009646199 @default.
• W2015246311 cites W2016760563 @default.
• W2015246311 cites W2021675664 @default.
• W2015246311 cites W2022628849 @default.
• W2015246311 cites W2023485487 @default.
• W2015246311 cites W2024233889 @default.
• W2015246311 cites W2024289681 @default.
• W2015246311 cites W2027372216 @default.
• W2015246311 cites W2030793740 @default.
• W2015246311 cites W2033498682 @default.
• W2015246311 cites W2034096429 @default.
• W2015246311 cites W2036362108 @default.
• W2015246311 cites W2037099926 @default.
• W2015246311 cites W2039453997 @default.
• W2015246311 cites W2042274378 @default.
• W2015246311 cites W2044750065 @default.
• W2015246311 cites W2046412053 @default.
• W2015246311 cites W2046454316 @default.
• W2015246311 cites W2047511834 @default.
• W2015246311 cites W2048510554 @default.
• W2015246311 cites W2050486145 @default.
• W2015246311 cites W2051776695 @default.
• W2015246311 cites W2055339554 @default.
• W2015246311 cites W2056384210 @default.
• W2015246311 cites W2065742642 @default.
• W2015246311 cites W2077290313 @default.
• W2015246311 cites W2082452384 @default.
• W2015246311 cites W2083556882 @default.
• W2015246311 cites W2083651943 @default.
• W2015246311 cites W2085857972 @default.
• W2015246311 cites W2091270633 @default.
• W2015246311 cites W2092193486 @default.
• W2015246311 cites W2094864822 @default.
• W2015246311 cites W2103071556 @default.
• W2015246311 cites W2105318758 @default.
• W2015246311 cites W2107010463 @default.
• W2015246311 cites W2107864895 @default.
• W2015246311 cites W2109728136 @default.
• W2015246311 cites W2111015407 @default.
• W2015246311 cites W2113690827 @default.
• W2015246311 cites W2119401431 @default.
• W2015246311 cites W2127401575 @default.
• W2015246311 cites W2130945157 @default.
• W2015246311 cites W2137497029 @default.
• W2015246311 cites W2146625461 @default.
• W2015246311 cites W2146957909 @default.
• W2015246311 cites W2147710510 @default.
• W2015246311 cites W2149650428 @default.
• W2015246311 cites W2151749372 @default.
• W2015246311 cites W2155894885 @default.
• W2015246311 cites W2156675756 @default.
• W2015246311 cites W2158960911 @default.
• W2015246311 cites W2158968701 @default.
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• W2015246311 cites W2167754585 @default.
• W2015246311 cites W2168390615 @default.
• W2015246311 cites W2168677934 @default.
• W2015246311 cites W2330496155 @default.
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• W2015246311 doi "https://doi.org/10.1002/ana.20774" @default.
• W2015246311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16402383" @default.
• W2015246311 hasPublicationYear "2006" @default.
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