FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015250401> ?p ?o ?g. }

• W2015250401 endingPage "e17738" @default.
• W2015250401 startingPage "e17738" @default.
• W2015250401 abstract "The molecular causes by which the epidermal growth factor receptor tyrosine kinase induces malignant transformation are largely unknown. To better understand EGFs' transforming capacity whole genome scans were applied to a transgenic mouse model of liver cancer and subjected to advanced methods of computational analysis to construct de novo gene regulatory networks based on a combination of sequence analysis and entrained graph-topological algorithms. Here we identified transcription factors, processes, key nodes and molecules to connect as yet unknown interacting partners at the level of protein-DNA interaction. Many of those could be confirmed by electromobility band shift assay at recognition sites of gene specific promoters and by western blotting of nuclear proteins. A novel cellular regulatory circuitry could therefore be proposed that connects cell cycle regulated genes with components of the EGF signaling pathway. Promoter analysis of differentially expressed genes suggested the majority of regulated transcription factors to display specificity to either the pre-tumor or the tumor state. Subsequent search for signal transduction key nodes upstream of the identified transcription factors and their targets suggested the insulin-like growth factor pathway to render the tumor cells independent of EGF receptor activity. Notably, expression of IGF2 in addition to many components of this pathway was highly upregulated in tumors. Together, we propose a switch in autocrine signaling to foster tumor growth that was initially triggered by EGF and demonstrate the knowledge gain form promoter analysis combined with upstream key node identification." @default.
• W2015250401 created "2016-06-24" @default.
• W2015250401 creator A5016954113 @default.
• W2015250401 creator A5028680421 @default.
• W2015250401 creator A5029172959 @default.
• W2015250401 creator A5055686660 @default.
• W2015250401 creator A5063806596 @default.
• W2015250401 creator A5077363176 @default.
• W2015250401 date "2011-03-28" @default.
• W2015250401 modified "2023-10-07" @default.
• W2015250401 title "Advanced Computational Biology Methods Identify Molecular Switches for Malignancy in an EGF Mouse Model of Liver Cancer" @default.
• W2015250401 cites W1533598723 @default.
• W2015250401 cites W1751375690 @default.
• W2015250401 cites W1762546725 @default.
• W2015250401 cites W1970034115 @default.
• W2015250401 cites W1986302429 @default.
• W2015250401 cites W1986841498 @default.
• W2015250401 cites W1996600671 @default.
• W2015250401 cites W2005631145 @default.
• W2015250401 cites W2005695308 @default.
• W2015250401 cites W2006170285 @default.
• W2015250401 cites W2007667157 @default.
• W2015250401 cites W2007685062 @default.
• W2015250401 cites W2012345849 @default.
• W2015250401 cites W2036986058 @default.
• W2015250401 cites W2046075717 @default.
• W2015250401 cites W2047772224 @default.
• W2015250401 cites W2047814129 @default.
• W2015250401 cites W2048579089 @default.
• W2015250401 cites W2049783720 @default.
• W2015250401 cites W2055206986 @default.
• W2015250401 cites W2057692691 @default.
• W2015250401 cites W2062393124 @default.
• W2015250401 cites W2067306349 @default.
• W2015250401 cites W2089255658 @default.
• W2015250401 cites W2094036688 @default.
• W2015250401 cites W2097375063 @default.
• W2015250401 cites W2099396594 @default.
• W2015250401 cites W2102160410 @default.
• W2015250401 cites W2102304447 @default.
• W2015250401 cites W2103017472 @default.
• W2015250401 cites W2115356458 @default.
• W2015250401 cites W2120772351 @default.
• W2015250401 cites W2121298930 @default.
• W2015250401 cites W2127774996 @default.
• W2015250401 cites W2133033425 @default.
• W2015250401 cites W2134193442 @default.
• W2015250401 cites W2135030836 @default.
• W2015250401 cites W2145120379 @default.
• W2015250401 cites W2146526187 @default.
• W2015250401 cites W2152501741 @default.
• W2015250401 cites W2160632611 @default.
• W2015250401 cites W2160697532 @default.
• W2015250401 cites W2163035954 @default.
• W2015250401 cites W2168665897 @default.
• W2015250401 cites W4210430020 @default.
• W2015250401 cites W4256153055 @default.
• W2015250401 doi "https://doi.org/10.1371/journal.pone.0017738" @default.
• W2015250401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3065454" @default.
• W2015250401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21464922" @default.
• W2015250401 hasPublicationYear "2011" @default.
• W2015250401 type Work @default.
• W2015250401 sameAs 2015250401 @default.
• W2015250401 citedByCount "16" @default.
• W2015250401 countsByYear W20152504012014 @default.
• W2015250401 countsByYear W20152504012015 @default.
• W2015250401 countsByYear W20152504012016 @default.
• W2015250401 countsByYear W20152504012017 @default.
• W2015250401 countsByYear W20152504012018 @default.
• W2015250401 countsByYear W20152504012019 @default.
• W2015250401 countsByYear W20152504012023 @default.
• W2015250401 crossrefType "journal-article" @default.
• W2015250401 hasAuthorship W2015250401A5016954113 @default.
• W2015250401 hasAuthorship W2015250401A5028680421 @default.
• W2015250401 hasAuthorship W2015250401A5029172959 @default.
• W2015250401 hasAuthorship W2015250401A5055686660 @default.
• W2015250401 hasAuthorship W2015250401A5063806596 @default.
• W2015250401 hasAuthorship W2015250401A5077363176 @default.
• W2015250401 hasBestOaLocation W20152504011 @default.
• W2015250401 hasConcept C101544691 @default.
• W2015250401 hasConcept C101762097 @default.
• W2015250401 hasConcept C104317684 @default.
• W2015250401 hasConcept C128240485 @default.
• W2015250401 hasConcept C150194340 @default.
• W2015250401 hasConcept C170493617 @default.
• W2015250401 hasConcept C2776362946 @default.
• W2015250401 hasConcept C502942594 @default.
• W2015250401 hasConcept C54355233 @default.
• W2015250401 hasConcept C62478195 @default.
• W2015250401 hasConcept C67339327 @default.
• W2015250401 hasConcept C70721500 @default.
• W2015250401 hasConcept C86339819 @default.
• W2015250401 hasConcept C86803240 @default.
• W2015250401 hasConcept C95444343 @default.
• W2015250401 hasConceptScore W2015250401C101544691 @default.
• W2015250401 hasConceptScore W2015250401C101762097 @default.
• W2015250401 hasConceptScore W2015250401C104317684 @default.
• W2015250401 hasConceptScore W2015250401C128240485 @default.

• next