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• W2015250440 abstract "Distension of the ischemic region has been related to an increased incidence of spontaneous ventricular arrhythmias following coronary occlusion. This study analyzed whether regional ischemic distension predicts increased ventricular fibrillation inducibility after coronary occlusion in swine. In 18 anesthetized, open-chest pigs, the left anterior descending coronary artery was ligated for 60 min. Myocardial segment length in the ischemic region was monitored by means of ultrasonic crystals. Programmed stimulation was applied at baseline and then continuously between 10 and 60 min after coronary occlusion. Coronary occlusion induced a rapid increase in end-diastolic length in the ischemic region, which reached 109.4% (0.9%) of baseline values 10 min after occlusion (P<.001). On average, 6.6 (0.5) stimulation protocols were completed and 5.4 (0.6) ventricular fibrillation episodes induced between 10 and 60 min of coronary occlusion. Neither baseline serum potassium levels nor the size of the ischemic region were significantly related to ventricular fibrillation inducibility. In contrast, the increase in end-diastolic length 10 min after coronary occlusion was associated directly (r=0.67; P=.002) with the number of induced ventricular fibrillation episodes and inversely (r=–0.55; P=.018) with the number of extrastimuli needed for ventricular fibrillation induction. Regional ischemic expansion predicts increased ventricular fibrillation inducibility following coronary occlusion. These results highlight the potential influence of mechanical factors, acting not only on the triggers but also on the substrate, in the genesis of malignant ventricular arrhythmias during acute ischemia. La distensión de la región isquémica se ha relacionado con una mayor incidencia de arritmias ventriculares espontáneas tras la oclusión coronaria. Analizamos si la distensión isquémica regional predice una mayor inducibilidad de fibrilación ventricular tras la oclusión coronaria en cerdos. En 18 cerdos anestesiados con tórax abierto, se ocluyó la descendente anterior durante 60 min. Se monitorizó la longitud segmentaria en la región isquémica mediante cristales ultrasónicos. Se realizó estimulación programada basal, y después continuamente entre 10 y 60 min tras la oclusión. La oclusión coronaria indujo un rápido aumento en la longitud telediastólica en la región isquémica, que alcanzó el 109,4 ± 0,9% de los valores basales a los 10 min (p < 0,001). Se completaron 6,6 ± 0,5 protocolos de estimulación, que indujeron 5,4 ± 0,6 episodios de fibrilación ventricular entre 10 y 60 min tras la oclusión. Ni los valores séricos de potasio ni el tamaño del área isquémica se asociaron significativamente con la inducibilidad de fibrilación ventricular. Por el contrario, el aumento en la longitud telediastólica 10 min tras la oclusión coronaria se asoció directamente (r = 0,67; p = 0,002) con el número de episodios inducidos de fibrilación ventricular e inversamente (r = –0,55; p = 0,018) con el número de extraestímulos necesarios para inducir la arritmia. La distensión regional isquémica predice una mayor inducibilidad de fibrilación ventricular tras la oclusión coronaria. Estos resultados subrayan la influencia potencial de los factores mecánicos, que actúan no sólo sobre los desencadenantes, sino también sobre el sustrato, en la génesis de las arritmias ventriculares malignas durante la isquemia aguda." @default.
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• W2015250440 date "2013-03-01" @default.
• W2015250440 modified "2023-10-16" @default.
• W2015250440 title "Distension of the Ischemic Region Predicts Increased Ventricular Fibrillation Inducibility Following Coronary Occlusion in Swine" @default.
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• W2015250440 doi "https://doi.org/10.1016/j.rec.2012.08.006" @default.
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