FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015250987> ?p ?o ?g. }

• W2015250987 endingPage "964" @default.
• W2015250987 startingPage "960" @default.
• W2015250987 abstract "Because previous investigations have suggested that platelet activating factor and tumor necrosis factor-alpha (TNF-α) are important mediators of experimental necrotizing enterocolitis in the rat, we measured platelet activating factor, acetylhydrolase (the platelet activating factor breakdown enzyme), and TNF-α in the plasma of 12 human neonates with necrotizing enterocolitis and eight age-matched control subjects with similar gestational ages, postnatal ages, and weights. Almost all patients with necrotizing enterocolitis had elevated plasma platelet activating factor values (18.1±3.6 ng/ml vs 3.1±0.9 ng/ml in control subjects, p<0.01). Plasma acetylhydrolase activity was lower in patients than in control subjects (10.6±0.7 nmol/ml/min vs 23.0±1.4 nmol/ml/min, p<0.01). Plasma TNF-α concentration was significantly elevated in patients with necrotizing enterocolitis (136±75U/ml vs 1.5±0.8U/ml, p<0.05), although the individual variation was high. There was no correlation between individual. TNF-α and platelet activating factor levels. We conclude that platelet activating factor and TNF-α are elevated in patients with necrotizing enterocolitis and that suppressed platelet activating factor degradation contributes to the increased platelet activating factor levels; platelet activating factor and TNF-α may contribute to the pathophysiology of necrotizing enterocolitis. Because previous investigations have suggested that platelet activating factor and tumor necrosis factor-alpha (TNF-α) are important mediators of experimental necrotizing enterocolitis in the rat, we measured platelet activating factor, acetylhydrolase (the platelet activating factor breakdown enzyme), and TNF-α in the plasma of 12 human neonates with necrotizing enterocolitis and eight age-matched control subjects with similar gestational ages, postnatal ages, and weights. Almost all patients with necrotizing enterocolitis had elevated plasma platelet activating factor values (18.1±3.6 ng/ml vs 3.1±0.9 ng/ml in control subjects, p<0.01). Plasma acetylhydrolase activity was lower in patients than in control subjects (10.6±0.7 nmol/ml/min vs 23.0±1.4 nmol/ml/min, p<0.01). Plasma TNF-α concentration was significantly elevated in patients with necrotizing enterocolitis (136±75U/ml vs 1.5±0.8U/ml, p<0.05), although the individual variation was high. There was no correlation between individual. TNF-α and platelet activating factor levels. We conclude that platelet activating factor and TNF-α are elevated in patients with necrotizing enterocolitis and that suppressed platelet activating factor degradation contributes to the increased platelet activating factor levels; platelet activating factor and TNF-α may contribute to the pathophysiology of necrotizing enterocolitis." @default.
• W2015250987 created "2016-06-24" @default.
• W2015250987 creator A5023105822 @default.
• W2015250987 creator A5029057757 @default.
• W2015250987 creator A5035909098 @default.
• W2015250987 creator A5039760813 @default.
• W2015250987 date "1990-06-01" @default.
• W2015250987 modified "2023-10-16" @default.
• W2015250987 title "Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis" @default.
• W2015250987 cites W1520762000 @default.
• W2015250987 cites W1968713831 @default.
• W2015250987 cites W1973313699 @default.
• W2015250987 cites W1982134056 @default.
• W2015250987 cites W1999246265 @default.
• W2015250987 cites W1999797629 @default.
• W2015250987 cites W2007451263 @default.
• W2015250987 cites W2011291552 @default.
• W2015250987 cites W2019549525 @default.
• W2015250987 cites W2040179836 @default.
• W2015250987 cites W2060767159 @default.
• W2015250987 cites W2068636501 @default.
• W2015250987 cites W2101157641 @default.
• W2015250987 cites W2101720275 @default.
• W2015250987 cites W2107396956 @default.
• W2015250987 cites W2118872783 @default.
• W2015250987 cites W2121121770 @default.
• W2015250987 cites W2126342903 @default.
• W2015250987 cites W2151677238 @default.
• W2015250987 cites W2168526937 @default.
• W2015250987 cites W2301034803 @default.
• W2015250987 cites W2323870293 @default.
• W2015250987 cites W4231420705 @default.
• W2015250987 doi "https://doi.org/10.1016/s0022-3476(05)80661-4" @default.
• W2015250987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2348301" @default.
• W2015250987 hasPublicationYear "1990" @default.
• W2015250987 type Work @default.
• W2015250987 sameAs 2015250987 @default.
• W2015250987 citedByCount "278" @default.
• W2015250987 countsByYear W20152509872012 @default.
• W2015250987 countsByYear W20152509872013 @default.
• W2015250987 countsByYear W20152509872014 @default.
• W2015250987 countsByYear W20152509872015 @default.
• W2015250987 countsByYear W20152509872016 @default.
• W2015250987 countsByYear W20152509872017 @default.
• W2015250987 countsByYear W20152509872018 @default.
• W2015250987 countsByYear W20152509872019 @default.
• W2015250987 countsByYear W20152509872020 @default.
• W2015250987 countsByYear W20152509872021 @default.
• W2015250987 countsByYear W20152509872022 @default.
• W2015250987 countsByYear W20152509872023 @default.
• W2015250987 crossrefType "journal-article" @default.
• W2015250987 hasAuthorship W2015250987A5023105822 @default.
• W2015250987 hasAuthorship W2015250987A5029057757 @default.
• W2015250987 hasAuthorship W2015250987A5035909098 @default.
• W2015250987 hasAuthorship W2015250987A5039760813 @default.
• W2015250987 hasConcept C126322002 @default.
• W2015250987 hasConcept C134018914 @default.
• W2015250987 hasConcept C17991360 @default.
• W2015250987 hasConcept C203014093 @default.
• W2015250987 hasConcept C2776258884 @default.
• W2015250987 hasConcept C2779020240 @default.
• W2015250987 hasConcept C2779303187 @default.
• W2015250987 hasConcept C71924100 @default.
• W2015250987 hasConcept C89560881 @default.
• W2015250987 hasConceptScore W2015250987C126322002 @default.
• W2015250987 hasConceptScore W2015250987C134018914 @default.
• W2015250987 hasConceptScore W2015250987C17991360 @default.
• W2015250987 hasConceptScore W2015250987C203014093 @default.
• W2015250987 hasConceptScore W2015250987C2776258884 @default.
• W2015250987 hasConceptScore W2015250987C2779020240 @default.
• W2015250987 hasConceptScore W2015250987C2779303187 @default.
• W2015250987 hasConceptScore W2015250987C71924100 @default.
• W2015250987 hasConceptScore W2015250987C89560881 @default.
• W2015250987 hasIssue "6" @default.
• W2015250987 hasLocation W20152509871 @default.
• W2015250987 hasLocation W20152509872 @default.
• W2015250987 hasOpenAccess W2015250987 @default.
• W2015250987 hasPrimaryLocation W20152509871 @default.
• W2015250987 hasRelatedWork W1509450179 @default.
• W2015250987 hasRelatedWork W2052737509 @default.
• W2015250987 hasRelatedWork W2054756716 @default.
• W2015250987 hasRelatedWork W2070077029 @default.
• W2015250987 hasRelatedWork W2082136782 @default.
• W2015250987 hasRelatedWork W2139847602 @default.
• W2015250987 hasRelatedWork W2325845343 @default.
• W2015250987 hasRelatedWork W2940540567 @default.
• W2015250987 hasRelatedWork W3015717938 @default.
• W2015250987 hasRelatedWork W2300046951 @default.
• W2015250987 hasVolume "116" @default.
• W2015250987 isParatext "false" @default.
• W2015250987 isRetracted "false" @default.
• W2015250987 magId "2015250987" @default.
• W2015250987 workType "article" @default.