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• W2015251934 abstract "NMR spectroscopy has been applied extensively to study metabolism noninvasively in the human brain and other tissues. However, it usually suffers from poor signal-to-noise ratio due to low NMR sensitivity and low metabolite concentrations. In this study, the technique of proton-observe-carbon-edited (POCE) NMR spectroscopy combined with a single-shot localization sequence was used to detect the natural abundance carbon signal of the amino acid N-acetyl aspartate from a 12-cm3 localized volume in the occipital lobe of humans at 4 T. The results suggest that NMR spectroscopy is sensitive enough to detect signals from low concentration metabolites (<60 nmol/g) from small volumes in the human brain within several minutes of data acquisition. This reveals that in vivo NMR spectroscopy is a promising technique for detecting small metabolite changes and low traces of 13C isotopic labeling for dynamic metabolism studies aimed at investigating physiological and pathological questions." @default.
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• W2015251934 date "1998-08-01" @default.
• W2015251934 modified "2023-10-12" @default.
• W2015251934 title "Detecting natural abundance carbon signal of NAA metabolite within 12-cm3 localized volume of human brain using1H-{13C} NMR spectroscopy" @default.
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• W2015251934 doi "https://doi.org/10.1002/mrm.1910400203" @default.
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