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• W2015254345 abstract "No AccessJournal of UrologyAdult Urology1 Aug 2012Impact of Histological Variants on Clinical Outcomes of Patients with Upper Urinary Tract Urothelial Carcinoma Michael Rink, Brian D. Robinson, David A. Green, Eugene K. Cha, Jens Hansen, Evi Comploj, Vitaly Margulis, Jay D. Raman, Casey K. Ng, Mesut Remzi, Karim Bensalah, Wareef Kabbani, Andrea Haitel, Nathalie Rioux-Leclercq, Charles C. Guo, Felix K. Chun, Eiji Kikuchi, Wassim Kassouf, Kanishka Sircar, Maxine Sun, Guru Sonpavde, Yair Lotan, Armin Pycha, Pierre I. Karakiewicz, Douglas S. Scherr, and Shahrokh F. Shariat Michael RinkMichael Rink Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York University Medical Center Hamburg-Eppendorf, Hamburg, Germany More articles by this author , Brian D. RobinsonBrian D. Robinson Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author , David A. GreenDavid A. Green Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author , Eugene K. ChaEugene K. Cha Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author , Jens HansenJens Hansen University Medical Center Hamburg-Eppendorf, Hamburg, Germany University of Montreal, Montreal, Quebec, Canada More articles by this author , Evi ComplojEvi Comploj General Hospital of Bolzano, Bolzano, Italy More articles by this author , Vitaly MargulisVitaly Margulis University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author , Jay D. RamanJay D. Raman Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania More articles by this author , Casey K. NgCasey K. Ng Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author , Mesut RemziMesut Remzi Hospital Korneuburg, Vienna, Austria More articles by this author , Karim BensalahKarim Bensalah University of Rennes, Rennes, France More articles by this author , Wareef KabbaniWareef Kabbani University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author , Andrea HaitelAndrea Haitel University of Vienna, Vienna, Austria More articles by this author , Nathalie Rioux-LeclercqNathalie Rioux-Leclercq University of Rennes, Rennes, France More articles by this author , Charles C. GuoCharles C. Guo M.D. Anderson Cancer Center, Houston, Texas More articles by this author , Felix K. ChunFelix K. Chun University Medical Center Hamburg-Eppendorf, Hamburg, Germany More articles by this author , Eiji KikuchiEiji Kikuchi Keio University School of Medicine, Tokyo, Japan More articles by this author , Wassim KassoufWassim Kassouf McGill University, Montreal, Quebec, Canada More articles by this author , Kanishka SircarKanishka Sircar McGill University, Montreal, Quebec, Canada More articles by this author , Maxine SunMaxine Sun University of Montreal, Montreal, Quebec, Canada More articles by this author , Guru SonpavdeGuru Sonpavde M.D. Anderson Cancer Center, Houston, Texas More articles by this author , Yair LotanYair Lotan University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author , Armin PychaArmin Pycha General Hospital of Bolzano, Bolzano, Italy More articles by this author , Pierre I. KarakiewiczPierre I. Karakiewicz University of Montreal, Montreal, Quebec, Canada More articles by this author , Douglas S. ScherrDouglas S. Scherr Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author , and Shahrokh F. ShariatShahrokh F. Shariat Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.04.009AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the clinical and prognostic impact of variant histologies on upper tract urothelial carcinoma outcomes after radical nephroureterectomy. Materials and Methods: Data on 1,648 patients with upper tract urothelial carcinoma treated with radical nephroureterectomy without preoperative chemotherapy or radiotherapy were reviewed for histological differentiation and variants. We analyzed differences between pure upper tract urothelial carcinoma and upper tract urothelial carcinoma with variant histology, and differences in the histological variants using different stratifications. Results: A total of 398 patients (24.2%) had histological upper tract urothelial carcinoma variants. The most common variants were squamous cell and glandular differentiation in 9.9% and 4.4% of cases, respectively. Histological variants were associated with advanced tumor stage, tumor multifocality, sessile tumor architecture, tumor necrosis, lymphovascular invasion and lymph node metastasis compared to pure upper tract urothelial carcinoma (p ≤0.031). On univariable analysis variant histology was associated with disease recurrence (p = 0.002) and cancer specific mortality (p = 0.003). In 174 patients treated with adjuvant chemotherapy there was no difference in disease recurrence or survival between variant histology and pure upper tract urothelial carcinoma (p = 0.42 and 0.59, respectively). On multivariable analysis adjusted for the effects of standard clinicopathological characteristics variant histology was not associated with either end point. Conclusions: Almost 25% of patients with upper tract urothelial carcinoma treated with radical nephroureterectomy harbored histological variants. Variant histology was associated with features of biologically aggressive upper tract urothelial carcinoma. While variant histology is associated with worse outcomes on univariable analysis but this effect did not remain significant on multivariable analysis. References 1 : Prognostic factors for upper urinary tract urothelial carcinoma. Nat Rev Urol2011; 8: 440. 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Google Scholar © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byNogueira L, Yip W, Assel M, Tracey A, Wong N, Alvim R, Al-Ahmadie H, Bajorin D and Coleman J (2022) Survival Impact of Variant Histology Diagnosis in Upper Tract Urothelial CarcinomaJournal of Urology, VOL. 208, NO. 4, (813-820), Online publication date: 1-Oct-2022.Mori K, Janisch F, Parizi M, Mostafaei H, Lysenko I, Kimura S, Enikeev D, Egawa S and Shariat S (2019) Prognostic Value of Variant Histology in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Systematic Review and Meta-AnalysisJournal of Urology, VOL. 203, NO. 6, (1075-1084), Online publication date: 1-Jun-2020.Laguna M (2017) Re: Efficacy of Systemic Chemotherapy plus Radical Nephroureterectomy for Metastatic Upper Tract Urothelial CarcinomaJournal of Urology, VOL. 198, NO. 6, (1205-1206), Online publication date: 1-Dec-2017.Rink M, Sharifi N, Fritsche H, Aziz A, Miller F, Kluth L, Ngamsri T, Dahlem R, Chun F, Shariat S, Stenzl A, Fisch M and Gakis G (2013) Impact of Preoperative Anemia on Oncologic Outcomes of Upper Tract Urothelial Carcinoma Treated with Radical NephroureterectomyJournal of Urology, VOL. 191, NO. 2, (316-322), Online publication date: 1-Feb-2014. Volume 188Issue 2August 2012Page: 398-404 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.KeywordscarcinomahistologykidneyurotheliumprognosisMetricsAuthor Information Michael Rink Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York University Medical Center Hamburg-Eppendorf, Hamburg, Germany More articles by this author Brian D. Robinson Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author David A. Green Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author Eugene K. Cha Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author Jens Hansen University Medical Center Hamburg-Eppendorf, Hamburg, Germany University of Montreal, Montreal, Quebec, Canada More articles by this author Evi Comploj General Hospital of Bolzano, Bolzano, Italy More articles by this author Vitaly Margulis University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author Jay D. Raman Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania More articles by this author Casey K. Ng Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author Mesut Remzi Hospital Korneuburg, Vienna, Austria More articles by this author Karim Bensalah University of Rennes, Rennes, France More articles by this author Wareef Kabbani University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author Andrea Haitel University of Vienna, Vienna, Austria More articles by this author Nathalie Rioux-Leclercq University of Rennes, Rennes, France More articles by this author Charles C. Guo M.D. Anderson Cancer Center, Houston, Texas More articles by this author Felix K. Chun University Medical Center Hamburg-Eppendorf, Hamburg, Germany More articles by this author Eiji Kikuchi Keio University School of Medicine, Tokyo, Japan More articles by this author Wassim Kassouf McGill University, Montreal, Quebec, Canada More articles by this author Kanishka Sircar McGill University, Montreal, Quebec, Canada More articles by this author Maxine Sun University of Montreal, Montreal, Quebec, Canada More articles by this author Guru Sonpavde M.D. Anderson Cancer Center, Houston, Texas More articles by this author Yair Lotan University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author Armin Pycha General Hospital of Bolzano, Bolzano, Italy More articles by this author Pierre I. Karakiewicz University of Montreal, Montreal, Quebec, Canada More articles by this author Douglas S. Scherr Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author Shahrokh F. Shariat Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2015254345 title "Impact of Histological Variants on Clinical Outcomes of Patients with Upper Urinary Tract Urothelial Carcinoma" @default.
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