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• W2015260011 endingPage "191" @default.
• W2015260011 startingPage "181" @default.
• W2015260011 abstract "Eye development is regulated by multiple agents including hormones and growth factors. Thyroid hormone (triiodothyronine, or T(3), and the prohormone thyroxine, or T(4)) plays a crucial role in the development of the central nervous system. Here we have examined the effects of low T(3)/T(4) levels (hypothyroid status) on the developing rat retina during the perinatal stage. Eyes from control (CG) and T(3)/T(4)-deficient (HG) fetuses (E19 and E21) and newborn (P0, P3, P5 and P7) rats were obtained by administering a chemical antithyroid solution (0.02% methyl-mercaptoimidazole +1% ClOK(4)) in the tap water to the dams and their offspring, from E9 and throughout gestation until they were killed. Perinatal eyes were processed for light and electron transmission microscopy and subjected to morphological and morphometric analyses. Low T(3)/T(4) levels led to decreased retinal growth during the perinatal stage. In addition, the retinas from the HG presented fewer neuroblasts than those of their euthyroid counterparts (at E21: 705 +/- 83 cells per constant area of 4 x 10(4) microm(2) vs. 440 +/- 60 cells per constant area of 4 x 10(4) microm(2); p = 0.010). During development the index of mitosis in the retina peaked at E21, falling at the end of the 1st postnatal week. Significantly lower values were observed in the HG (at P5: 0.803 +/- 0.374 mitoses/cells % vs. 0.349 +/- 0.180 mitoses/cells %; p = 0.004). Furthermore, we have found that low T(3)/T(4) levels delayed and/or altered a series of developmental processes occurring in the retina during the perinatal stage such as layering and differentiation of several cell types. Our results demonstrate that thyroid hormone regulates rat neuroretinogenesis." @default.
• W2015260011 created "2016-06-24" @default.
• W2015260011 creator A5004678552 @default.
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• W2015260011 date "2002-01-01" @default.
• W2015260011 modified "2023-10-16" @default.
• W2015260011 title "Low Thyroid Hormone Levels Impair the Perinatal Development of the Rat Retina" @default.
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• W2015260011 doi "https://doi.org/10.1159/000063885" @default.
• W2015260011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12297689" @default.
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