FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015263527> ?p ?o ?g. }

• W2015263527 endingPage "1494" @default.
• W2015263527 startingPage "1482" @default.
• W2015263527 abstract "TNF receptor-associated protein 1 (TRAP1) is an HSP90 chaperone involved in stress protection and apoptosis in mitochondrial and extramitochondrial compartments. Remarkably, aberrant deregulation of TRAP1 function has been observed in several cancer types with potential new opportunities for therapeutic intervention in humans. Although previous studies by our group identified novel roles of TRAP1 in quality control of mitochondria-destined proteins through the attenuation of protein synthesis, molecular mechanisms are still largely unknown. To shed further light on the signaling pathways regulated by TRAP1 in the attenuation of protein synthesis, this study demonstrates that the entire pathway of cap-mediated translation is activated in cells following TRAP1 interference: consistently, expression and consequent phosphorylation of p70S6K and RSK1, two translation activating kinases, are increased upon TRAP1 silencing. Furthermore, we show that these regulatory functions affect the response to translational stress and cell migration in wound healing assays, processes involving both kinases. Notably, the regulatory mechanisms controlled by TRAP1 are conserved in colorectal cancer tissues, since an inverse correlation between TRAP1 and p70S6K expression is found in tumor tissues, thereby supporting the relevant role of TRAP1 translational regulation in vivo. Taken as a whole, these new findings candidate TRAP1 network for new anti-cancer strategies aimed at targeting the translational/quality control machinery of tumor cells." @default.
• W2015263527 created "2016-06-24" @default.
• W2015263527 creator A5000751278 @default.
• W2015263527 creator A5005256026 @default.
• W2015263527 creator A5010559788 @default.
• W2015263527 creator A5017663750 @default.
• W2015263527 creator A5023688965 @default.
• W2015263527 creator A5041111657 @default.
• W2015263527 creator A5046454960 @default.
• W2015263527 creator A5047727108 @default.
• W2015263527 creator A5055132521 @default.
• W2015263527 creator A5083874541 @default.
• W2015263527 creator A5085697877 @default.
• W2015263527 creator A5087323696 @default.
• W2015263527 date "2014-06-13" @default.
• W2015263527 modified "2023-10-16" @default.
• W2015263527 title "TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: Relevance in human colorectal tumors" @default.
• W2015263527 cites W1501966284 @default.
• W2015263527 cites W1566306122 @default.
• W2015263527 cites W1964221844 @default.
• W2015263527 cites W1968766433 @default.
• W2015263527 cites W1971108880 @default.
• W2015263527 cites W1972125241 @default.
• W2015263527 cites W1982936419 @default.
• W2015263527 cites W1990232844 @default.
• W2015263527 cites W1999381474 @default.
• W2015263527 cites W2013182409 @default.
• W2015263527 cites W2015644600 @default.
• W2015263527 cites W2017057004 @default.
• W2015263527 cites W2025748302 @default.
• W2015263527 cites W2025827615 @default.
• W2015263527 cites W2029103952 @default.
• W2015263527 cites W2029631044 @default.
• W2015263527 cites W2033489247 @default.
• W2015263527 cites W2035409136 @default.
• W2015263527 cites W2042604012 @default.
• W2015263527 cites W2046518996 @default.
• W2015263527 cites W2047367472 @default.
• W2015263527 cites W2067024190 @default.
• W2015263527 cites W2071672251 @default.
• W2015263527 cites W2074176490 @default.
• W2015263527 cites W2079158153 @default.
• W2015263527 cites W2080525519 @default.
• W2015263527 cites W2095748631 @default.
• W2015263527 cites W2098108537 @default.
• W2015263527 cites W2099540110 @default.
• W2015263527 cites W2105029267 @default.
• W2015263527 cites W2110400064 @default.
• W2015263527 cites W2122127456 @default.
• W2015263527 cites W2129955038 @default.
• W2015263527 cites W2130461458 @default.
• W2015263527 cites W2140899494 @default.
• W2015263527 cites W2150301412 @default.
• W2015263527 cites W2150351516 @default.
• W2015263527 cites W2156704285 @default.
• W2015263527 cites W2161011316 @default.
• W2015263527 cites W2162697298 @default.
• W2015263527 cites W2163106706 @default.
• W2015263527 cites W2165341580 @default.
• W2015263527 cites W2168379252 @default.
• W2015263527 doi "https://doi.org/10.1016/j.molonc.2014.06.003" @default.
• W2015263527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5528605" @default.
• W2015263527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24962791" @default.
• W2015263527 hasPublicationYear "2014" @default.
• W2015263527 type Work @default.
• W2015263527 sameAs 2015263527 @default.
• W2015263527 citedByCount "30" @default.
• W2015263527 countsByYear W20152635272014 @default.
• W2015263527 countsByYear W20152635272015 @default.
• W2015263527 countsByYear W20152635272016 @default.
• W2015263527 countsByYear W20152635272017 @default.
• W2015263527 countsByYear W20152635272018 @default.
• W2015263527 countsByYear W20152635272019 @default.
• W2015263527 countsByYear W20152635272020 @default.
• W2015263527 countsByYear W20152635272021 @default.
• W2015263527 countsByYear W20152635272022 @default.
• W2015263527 countsByYear W20152635272023 @default.
• W2015263527 crossrefType "journal-article" @default.
• W2015263527 hasAuthorship W2015263527A5000751278 @default.
• W2015263527 hasAuthorship W2015263527A5005256026 @default.
• W2015263527 hasAuthorship W2015263527A5010559788 @default.
• W2015263527 hasAuthorship W2015263527A5017663750 @default.
• W2015263527 hasAuthorship W2015263527A5023688965 @default.
• W2015263527 hasAuthorship W2015263527A5041111657 @default.
• W2015263527 hasAuthorship W2015263527A5046454960 @default.
• W2015263527 hasAuthorship W2015263527A5047727108 @default.
• W2015263527 hasAuthorship W2015263527A5055132521 @default.
• W2015263527 hasAuthorship W2015263527A5083874541 @default.
• W2015263527 hasAuthorship W2015263527A5085697877 @default.
• W2015263527 hasAuthorship W2015263527A5087323696 @default.
• W2015263527 hasBestOaLocation W20152635271 @default.
• W2015263527 hasConcept C104317684 @default.
• W2015263527 hasConcept C104615370 @default.
• W2015263527 hasConcept C105580179 @default.
• W2015263527 hasConcept C119056186 @default.
• W2015263527 hasConcept C11960822 @default.
• W2015263527 hasConcept C142724271 @default.
• W2015263527 hasConcept C149364088 @default.

• next