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- W2015263614 abstract "The effects of tumor necrosis factor-α (TNF-α) on DNA synthesis in AH66 rat hepatoma cells and rat hepatocytes were analysed by means of [3H]thymidine incorporation. DNA synthesis in AH66 cells was suppressed when AH66 cells were directly incubated with TNF-α. When primary culture of rat Kupffer cells was incubated with hepatocyte conditioned media pretreated with TNF-α (0–200 U/ml), and AH66 cells were then treated with these hepatocyte/Kupffer cell-conditioned media, TNF-α used in the pretreatment caused a dose-dependent increase in DNA synthesis in AH66 cells with a maximum effect amounting to a more than 10-fold increase. In contrast, DNA synthesis in primary culture of rat hepatocytes was not stimulated by the TNF-α-pretreated hepatocyte/Kupffer cell conditioned media. These results suggest that TNF-α-mediated hepatocyte-Kupffer cell interaction selectively promotes proliferation of rat hepatoma cells." @default.
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- W2015263614 date "1992-03-01" @default.
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- W2015263614 title "Enhanced DNA synthesis in rat hepatoma cells by conditioned media from Kupffer cells incubated with supernatants of tumor necrosis factor-α-pretreated hepatocytes" @default.
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- W2015263614 doi "https://doi.org/10.1016/s0006-291x(05)80310-9" @default.
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