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- W2015264916 abstract "Abstract The combinative effect of Azone (AZ) and oleic acid (OA) on the large intestinal absorption of poorly absorbable drugs was investigated using the in situ closed loop method in rat. 6-Carboxylfluorescein (CF) was used as a poorly absorbable model drug. We used two formulae as follows: (1) HCO-60 micellar solution of AZ and/or OA; and (2) ufasomes, oleic acid vesicles, incorporating AZ (OA-AZ/ufasomes). The micellar solution of OA or AZ extremely enhanced the absorption of CF. Either the absorption promoting effect of OA or AZ in micellar solutions was dependent on the concentration of the adjuvant and reached the maximum level over about 20 mM. The combination of OA and AZ in micellar state showed approximately an additive effect. Also OA-AZ/ufasomes promoted the absorption of CF, as well as the micellar solutions but these effects were smaller than that obtained with micellar solutions. Moreover, from the results of CF-free ufasomes compared with ufasomes encapsulating CF, it was suggested that CF encapsulated in ufasomes could hardly be absorbed, and that the absorption of CF leaking out from ufasomes could be extensively enhanced." @default.
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- W2015264916 date "1986-08-01" @default.
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- W2015264916 title "Combinative promotion effect of Azone and fusogenic fatty acid on the large intestinal absorption in rat" @default.
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