Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015272213> ?p ?o ?g. }
- W2015272213 endingPage "4776" @default.
- W2015272213 startingPage "4766" @default.
- W2015272213 abstract "Yin-Yang 1 (YY1) is a ubiquitously expressed zinc finger transcription factor. It regulates a vast array of genes playing critical roles in development, differentiation, and cell cycle. Very little is known about the mechanisms that regulate the functions of YY1. It has long been proposed that YY1 is a phosphoprotein; however, a direct link between phosphorylation and the function of YY1 has never been proven. Investigation of the localization of YY1 during mitosis shows that it is distributed to the cytoplasm during prophase and remains excluded from DNA until early telophase. Immunostaining studies show that YY1 is distributed equally between daughter cells and rapidly associates with decondensing chromosomes in telophase, suggesting a role for YY1 in early marking of active and repressed genes. The exclusion of YY1 from DNA in prometaphase HeLa cells correlated with an increase in the phosphorylation of YY1 and loss of DNA-binding activity that can be reversed by dephosphorylation. We have mapped three phosphorylation sites on YY1 during mitosis and show that phosphorylation of two of these sites can abolish the DNA-binding activity of YY1. These results demonstrate a novel mechanism for the inactivation of YY1 through phosphorylation of its DNA-binding domain." @default.
- W2015272213 created "2016-06-24" @default.
- W2015272213 creator A5013708533 @default.
- W2015272213 creator A5014352567 @default.
- W2015272213 date "2009-11-15" @default.
- W2015272213 modified "2023-10-09" @default.
- W2015272213 title "Regulation of the Transcription Factor YY1 in Mitosis through Phosphorylation of Its DNA-binding Domain" @default.
- W2015272213 cites W1500525948 @default.
- W2015272213 cites W1511309214 @default.
- W2015272213 cites W1534988355 @default.
- W2015272213 cites W1550055479 @default.
- W2015272213 cites W1824346003 @default.
- W2015272213 cites W1938103646 @default.
- W2015272213 cites W1943233864 @default.
- W2015272213 cites W1965398400 @default.
- W2015272213 cites W1965581435 @default.
- W2015272213 cites W1966156883 @default.
- W2015272213 cites W1976834761 @default.
- W2015272213 cites W1980489315 @default.
- W2015272213 cites W1981327848 @default.
- W2015272213 cites W1981593440 @default.
- W2015272213 cites W1996853399 @default.
- W2015272213 cites W1999074203 @default.
- W2015272213 cites W2002644225 @default.
- W2015272213 cites W2005462392 @default.
- W2015272213 cites W2007026781 @default.
- W2015272213 cites W2008431386 @default.
- W2015272213 cites W2010714974 @default.
- W2015272213 cites W2012222076 @default.
- W2015272213 cites W2013224893 @default.
- W2015272213 cites W2013289541 @default.
- W2015272213 cites W2016311718 @default.
- W2015272213 cites W2017050402 @default.
- W2015272213 cites W2023559790 @default.
- W2015272213 cites W2023887736 @default.
- W2015272213 cites W2026333608 @default.
- W2015272213 cites W2035657750 @default.
- W2015272213 cites W2036160367 @default.
- W2015272213 cites W2036733966 @default.
- W2015272213 cites W2038013843 @default.
- W2015272213 cites W2039479984 @default.
- W2015272213 cites W2042315437 @default.
- W2015272213 cites W2045752058 @default.
- W2015272213 cites W2049518601 @default.
- W2015272213 cites W2051298961 @default.
- W2015272213 cites W2051373106 @default.
- W2015272213 cites W2055086507 @default.
- W2015272213 cites W2058144279 @default.
- W2015272213 cites W2063460322 @default.
- W2015272213 cites W2068972095 @default.
- W2015272213 cites W2076238001 @default.
- W2015272213 cites W2077804275 @default.
- W2015272213 cites W2078830718 @default.
- W2015272213 cites W2082213640 @default.
- W2015272213 cites W2082496903 @default.
- W2015272213 cites W2086154375 @default.
- W2015272213 cites W2087427344 @default.
- W2015272213 cites W2104744253 @default.
- W2015272213 cites W2105712639 @default.
- W2015272213 cites W2106582601 @default.
- W2015272213 cites W2113481120 @default.
- W2015272213 cites W2113556902 @default.
- W2015272213 cites W2113689543 @default.
- W2015272213 cites W2116552695 @default.
- W2015272213 cites W2119093680 @default.
- W2015272213 cites W2120433843 @default.
- W2015272213 cites W2123711995 @default.
- W2015272213 cites W2129665088 @default.
- W2015272213 cites W2130418521 @default.
- W2015272213 cites W2143168873 @default.
- W2015272213 cites W2154892337 @default.
- W2015272213 cites W2162111156 @default.
- W2015272213 cites W2163098987 @default.
- W2015272213 cites W2164380111 @default.
- W2015272213 cites W2168367974 @default.
- W2015272213 cites W2318098426 @default.
- W2015272213 doi "https://doi.org/10.1091/mbc.e09-04-0264" @default.
- W2015272213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2777106" @default.
- W2015272213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19793915" @default.
- W2015272213 hasPublicationYear "2009" @default.
- W2015272213 type Work @default.
- W2015272213 sameAs 2015272213 @default.
- W2015272213 citedByCount "66" @default.
- W2015272213 countsByYear W20152722132012 @default.
- W2015272213 countsByYear W20152722132013 @default.
- W2015272213 countsByYear W20152722132014 @default.
- W2015272213 countsByYear W20152722132015 @default.
- W2015272213 countsByYear W20152722132016 @default.
- W2015272213 countsByYear W20152722132017 @default.
- W2015272213 countsByYear W20152722132018 @default.
- W2015272213 countsByYear W20152722132019 @default.
- W2015272213 countsByYear W20152722132020 @default.
- W2015272213 countsByYear W20152722132021 @default.
- W2015272213 countsByYear W20152722132022 @default.
- W2015272213 countsByYear W20152722132023 @default.
- W2015272213 crossrefType "journal-article" @default.
- W2015272213 hasAuthorship W2015272213A5013708533 @default.
- W2015272213 hasAuthorship W2015272213A5014352567 @default.