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• W2015275093 abstract "The gene for the regulatory subunit RIIα of cAMP-dependent protein kinase is highly regulated during spermatogenesis and a strong signal from a distinct short mRNA form is observed postmeiotically during spermatid elongation. This report presents the isolation and characterization of the 5′-flanking region (1.2 kb) and exon 1 of the human RIIα gene. S1 nuclease mapping and primer extension experiments revealed the presence of a major transcriptional start site located 208 nucleotides upstream of start for translation. The 5′-flanking region of the RIIα gene did not contain a TATA box and was highly G/C-rich. A basal promoter directing high levels of chloramphenicol acetyl transferase (CAT) activity was identified in the 5′-flanking sequence. Several potential binding sites for transcription factors were identified in this region, which may be responsible for the germ cell-specific regulation of this gene. We have previously reported that the human testis RIIα cDNA contains a region (amino acids 45-75) with little or no homology to the corresponding rat skeletal muscle cDNA (Øyen, O., Myklebust, F., Scott, J.D., Cadd, G.G., McKnight, G.S., Hansson, V. and Jahnsen, T. (1990) Biol. Reprod. 43, 46–54). We examined whether this difference could arise due to organ-specific splice mechanisms or represented a species difference. We show that the low homology region of the human RIIα cDNA resides entirely within exon 1, and does not originate from a tissue-specific alternate splicing of this distinct region." @default.
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• W2015275093 date "1997-01-01" @default.
• W2015275093 modified "2023-10-16" @default.
• W2015275093 title "Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RIIα of cAMP-dependent protein kinase" @default.
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• W2015275093 doi "https://doi.org/10.1016/s0167-4781(96)00152-2" @default.
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