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• W2015276198 abstract "Cardiac myocytes express the calcium-responsive nitric oxide synthase (eNOS or NOS3). Activation of NOS3 by increased intracellular Ca2+concentration, [Ca2+]i, has been demonstrated to decrease myocyte contractile responsiveness, although this appears to occur in a Ca2+-independent manner. Therefore, the aim of this study was to examine the possibility that contractile activity could be modulated by an NO-mediated alteration in the phosphorylation status of troponin I, which is known to alter myofilament sensitivity to Ca2+. During pacing at 3 Hz,32P-labeled myocytes exhibited a 59 ± 9% increase in TnI phosphorylation compared to quiescent cells (p< 0.05), an effect that was significantly attenuated by either methylene blue orl-nitroarginine (l-NA). While exposure to methylene blue significantly increased the contractile amplitude of paced myocytes, this was not accompanied by an alteration in intracellular Ca2+. These data indicate that the NO-mediated effects on myocyte contraction may be elicited through an alteration in myofilament Ca2+sensitivity that results from an alteration in the phosphorylation status of troponin I." @default.
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• W2015276198 date "1999-03-01" @default.
• W2015276198 modified "2023-10-17" @default.
• W2015276198 title "Activation of Nitric Oxide Synthase (NOS3) by Mechanical Activity Alters Contractile Activity in a Ca2+-Independent Manner in Cardiac Myocytes: Role of Troponin I Phosphorylation" @default.
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• W2015276198 doi "https://doi.org/10.1006/bbrc.1999.0346" @default.
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