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- W2015280506 abstract "The action of several free radical scavengers and anti-inflammatory drugs to decrease the viscosity of the synovial fluid induced by the reaction between hypoxanthine and xanthine oxidase is evaluated. It confirms the significance of the hydroxyl and Superoxide radicals in the synovial fluid degradation and it shows that, with 1,3 diphenilisobenzofuran, singlet oxygen is generated in the xanthine oxidase reaction and suggests that it plays a role in the synovial fluid deterioration. The nonsteroidal anti-inflammatory drugs (Indometacine > Niflumic Acid > Acetaminophen > Imidazole > Mefenamic Acid > Phenylbutazone) as well as the steroidal ones (Prednisone > Dexamethasone > Triamcinolone Acetonide > Hydrocortisone) at 80 μM show the capacity to inhibit the synovial fluid degradation in the indicated order. Acetylsalicylic Acid is inactive. Paradoxically, Acetaminophen and Imidazole are more active for this system than as anti-inflammatory agents. To conclude, the results presented in this paper indicate that the capacity of anti-inflammatory dugs to inhibit the synovial fluid degradation is due to their ability to absorb or destroy free radicals." @default.
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- W2015280506 title "Synovial fluid degradation induced by free radicals. In vitro action of several free radical scavengers and anti-inflammatory drugs" @default.
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- W2015280506 doi "https://doi.org/10.1016/0006-2952(78)90390-8" @default.
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