Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015281331> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2015281331 endingPage "107" @default.
- W2015281331 startingPage "104" @default.
- W2015281331 abstract "Previous studies have shown that metronidazole is an effective chemotherapeutic agent in the treatment of certain types of periodontal disease. The purpose of this study was to assess, over 18 hours, the concentration of the drug in serum and gingival crevicular fluid after a single oral dose. Six female volunteers with gingivitis created by cessation of brushing for 2 weeks, took 250 mg of metronidazole orally. Micropipettes were used to collect 20 μ l of serum and 4 to 5 μ l of gingival fluid hourly for 8 hours, and at the 12th and 18th hours. Samples were assayed with a high pressure liquid Chromatograph. Mean drug levels in serum closely matched those reported by Stephen et al. ( Br Dent J l: 313, 1966) with polography. Mean serum drug levels peaked at 6.09 μ g/ml at the 2nd hour, and mean gingival crevicular fluid drug levels peaked at 3.62 μ g/ml at the 2nd and 7th hours. The drug was detectable in both fluids for up to 18 hours. Mean serum concentrations remained greater than mean gingival fluid concentrations at all time intervals, though the differences were not significant ( P < 0.05) as determined by a Hotelings' T 2 test. Using reported minimal inhibitory concentration values of metronidazole for various periodontopathogens, it was concluded that a single oral dose of metronidazole will deliver potentially inhibitory levels of the drug to the periodontium in serum and in gingival crevicular fluid." @default.
- W2015281331 created "2016-06-24" @default.
- W2015281331 creator A5085802239 @default.
- W2015281331 creator A5091160996 @default.
- W2015281331 date "1986-02-01" @default.
- W2015281331 modified "2023-09-24" @default.
- W2015281331 title "Serum and Crevicular Fluid Concentrations after a Single Oral Dose of Metronidazole" @default.
- W2015281331 cites W1849876075 @default.
- W2015281331 cites W1963776163 @default.
- W2015281331 cites W1965719715 @default.
- W2015281331 cites W1970037640 @default.
- W2015281331 cites W1984999536 @default.
- W2015281331 cites W1985186267 @default.
- W2015281331 cites W1988284345 @default.
- W2015281331 cites W1990261254 @default.
- W2015281331 cites W1993745864 @default.
- W2015281331 cites W2001283143 @default.
- W2015281331 cites W2005234006 @default.
- W2015281331 cites W2005372482 @default.
- W2015281331 cites W2009857353 @default.
- W2015281331 cites W2022170347 @default.
- W2015281331 cites W2033615887 @default.
- W2015281331 cites W2079733537 @default.
- W2015281331 cites W2079755813 @default.
- W2015281331 cites W2095164320 @default.
- W2015281331 cites W2104254700 @default.
- W2015281331 cites W2116694551 @default.
- W2015281331 cites W2148401329 @default.
- W2015281331 cites W2153289338 @default.
- W2015281331 cites W2162937347 @default.
- W2015281331 cites W2166437880 @default.
- W2015281331 doi "https://doi.org/10.1902/jop.1986.57.2.104" @default.
- W2015281331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3514837" @default.
- W2015281331 hasPublicationYear "1986" @default.
- W2015281331 type Work @default.
- W2015281331 sameAs 2015281331 @default.
- W2015281331 citedByCount "47" @default.
- W2015281331 countsByYear W20152813312012 @default.
- W2015281331 countsByYear W20152813312013 @default.
- W2015281331 countsByYear W20152813312014 @default.
- W2015281331 countsByYear W20152813312021 @default.
- W2015281331 crossrefType "journal-article" @default.
- W2015281331 hasAuthorship W2015281331A5085802239 @default.
- W2015281331 hasAuthorship W2015281331A5091160996 @default.
- W2015281331 hasConcept C185592680 @default.
- W2015281331 hasConcept C199343813 @default.
- W2015281331 hasConcept C2777396551 @default.
- W2015281331 hasConcept C2780035454 @default.
- W2015281331 hasConcept C2780385504 @default.
- W2015281331 hasConcept C2780791200 @default.
- W2015281331 hasConcept C501593827 @default.
- W2015281331 hasConcept C55493867 @default.
- W2015281331 hasConcept C58747440 @default.
- W2015281331 hasConcept C71924100 @default.
- W2015281331 hasConcept C98274493 @default.
- W2015281331 hasConceptScore W2015281331C185592680 @default.
- W2015281331 hasConceptScore W2015281331C199343813 @default.
- W2015281331 hasConceptScore W2015281331C2777396551 @default.
- W2015281331 hasConceptScore W2015281331C2780035454 @default.
- W2015281331 hasConceptScore W2015281331C2780385504 @default.
- W2015281331 hasConceptScore W2015281331C2780791200 @default.
- W2015281331 hasConceptScore W2015281331C501593827 @default.
- W2015281331 hasConceptScore W2015281331C55493867 @default.
- W2015281331 hasConceptScore W2015281331C58747440 @default.
- W2015281331 hasConceptScore W2015281331C71924100 @default.
- W2015281331 hasConceptScore W2015281331C98274493 @default.
- W2015281331 hasIssue "2" @default.
- W2015281331 hasLocation W20152813311 @default.
- W2015281331 hasLocation W20152813312 @default.
- W2015281331 hasOpenAccess W2015281331 @default.
- W2015281331 hasPrimaryLocation W20152813311 @default.
- W2015281331 hasRelatedWork W2030459373 @default.
- W2015281331 hasRelatedWork W2043686800 @default.
- W2015281331 hasRelatedWork W2098758817 @default.
- W2015281331 hasRelatedWork W2131624931 @default.
- W2015281331 hasRelatedWork W2131692139 @default.
- W2015281331 hasRelatedWork W2352858914 @default.
- W2015281331 hasRelatedWork W2413950955 @default.
- W2015281331 hasRelatedWork W2595675973 @default.
- W2015281331 hasRelatedWork W2934777198 @default.
- W2015281331 hasRelatedWork W2994923874 @default.
- W2015281331 hasVolume "57" @default.
- W2015281331 isParatext "false" @default.
- W2015281331 isRetracted "false" @default.
- W2015281331 magId "2015281331" @default.
- W2015281331 workType "article" @default.