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• W2015285939 abstract "<i>Background:</i> Midazolam sedation and morphine analgesia are commonly used in ventilated premature infants. <i>Objectives:</i> To evaluate the effects of midazolam versus morphine infusion on cerebral oxygenation and hemodynamics in ventilated premature infants. <i>Methods:</i> 11 patients (GA 26.6–33.0 weeks, BW 780–2,335 g) were sedated with midazolam (loading dose 0.2 mg/kg, maintenance 0.2 mg/kg/h) and 10 patients (GA 26.4–33.3 weeks, BW 842–1,955 g) were sedated with morphine (loading dose 0.05 mg/kg, maintenance 0.01 mg/kg/h). Changes in oxyhemoglobin (Δ<i>c</i>O₂Hb) and deoxyhemoglobin (Δ<i>c</i>HHb) were assessed using near infrared spectrophotometry. Changes in <i>c</i>HbD (= Δ<i>c</i>O₂Hb – Δ<i>c</i>HHb) reflect changes in cerebral blood oxygenation and changes in concentration of total hemoglobin (Δ<i>c</i>tHb = Δ<i>c</i>O₂Hb + Δ<i>c</i>HHb) represent changes in cerebral blood volume (ΔCBV). Changes in cerebral blood flow velocity (ΔCBFV) were intermittently measured using Doppler ultrasound. Heart rate (HR), mean arterial blood pressure (MABP), arterial oxygen saturation (<i>s</i>aO₂) and transcutaneous measured <i>p</i>O₂ (tc<i>p</i>O₂) and <i>p</i>CO₂ (tc<i>p</i>CO₂) were continuously registered. Statistical analyses were carried out using linear mixed models to account for the longitudinal character study design. <i>Results:</i> Within 15 min after the loading dose of midazolam, a decrease in<i> s</i>aO_2,tc<i>p</i>O₂and <i>c</i>HbD was observed in 5/11 infants. In addition, a fall in MABP and CBFV was observed 15 min after midazolam administration. Immediately after morphine infusion a decrease in<i> s</i>aO_2, tc<i>p</i>O₂and <i>c</i>HbD was observed in 6/10 infants. Furthermore, morphine infusion resulted in a persistent increase in CBV. <i>Conclusions:</i> Administration of midazolam and morphine in ventilated premature infants causes significant changes in cerebral oxygenation and hemodynamics, which might be harmful." @default.
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• W2015285939 date "2006-01-01" @default.
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• W2015285939 title "Effects of Midazolam and Morphine on Cerebral Oxygenation and Hemodynamics in Ventilated Premature Infants" @default.
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• W2015285939 doi "https://doi.org/10.1159/000093489" @default.
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