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- W2015294003 abstract "In general, the treatment of animals with 5-azacytidine (1-β-D-ribofuranosly-4-amino-s-triazine-2(1H)-one) was found to lead to a specific reduction of the 5-methylcytidine (m5C) content of tRNA in tissues, e.g. liver, hepatoma, mammary tumor, and spleen; however, the effect of the drug on post-transcriptional tRNA modification was more general in lymph nodes and in leukemic cells. Many base modifications of L1210 cell tRNA were inhibited, with m5C and dihydrouridine (hU) being affected the most. A positive correlation existed between the extent of inhibition of the formation of m5C and other modified nucleosides and the antitumor activity of the drug." @default.
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- W2015294003 date "1980-08-01" @default.
- W2015294003 modified "2023-09-26" @default.
- W2015294003 title "Effects of 5-azacytidine on transfer RNA modification: Comparative study on normal and malignant tissues" @default.
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- W2015294003 doi "https://doi.org/10.1016/0024-3205(80)90307-0" @default.
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