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- W2015302705 abstract "The effect of pertussis toxin pretreatment on electrophysiological responses to selective δ- and μ-opioid receptor agonists was examined in rat hippocampal brain slices. The evoked population spike response in the CA1 region following activation of the Schaffer collateral and commissural afferents was increased following perfusion with the δ-selective agonist [d-Pen2,d-Pen5enkephalin (DPDPE), and with the μ-selective agonist [d-Ala2,NMe-Phe4,Gly(O)5ol]enkephalin (DAGO). Both effects were significantly reduced or abolished in brain slices obtained from animals that had been pretreated with pertussis toxin 2–3 days earlier. These findings suggest that the excitatory responses to opioid agonists in hippocampus are the result of interactions with receptors that are coupled via pertussis toxin sensitive GTP-binding proteins to their respective effector mechanisms." @default.
- W2015302705 created "2016-06-24" @default.
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- W2015302705 date "1988-12-01" @default.
- W2015302705 modified "2023-09-27" @default.
- W2015302705 title "Pertussis toxin pretreatment antagonizes the actions of μ- and δ-opiate agonists in hippocampal slices" @default.
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- W2015302705 doi "https://doi.org/10.1016/0304-3940(88)90680-5" @default.
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