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• W2015304433 abstract "In many invertebrates and plants, the N-glycosylation profile is dominated by truncated paucimannosidic N-glycans, i.e. glycans consisting of a simple trimannosylchitobiosyl core often modified by core fucose residues. Even though they lack antennal N-acetylglucosamine residues, the biosynthesis of these glycans requires the sequential action of GlcNAc transferase I, Golgi mannosidase II, and, finally, beta-N-acetylglucosaminidases. In Drosophila, the recently characterized enzyme encoded by the fused lobes (fdl) gene specifically removes the non-reducing N-acetylglucosamine residue from the alpha1,3-antenna of N-glycans. In the present study, we examined the products of five beta-N-acetylhexosaminidase genes from Caenorhabditis elegans (hex-1 to hex-5, corresponding to reading frames T14F9.3, C14C11.3, Y39A1C.4, Y51F10.5, and Y70D2A.2) in addition to three from Arabidopsis thaliana (AtHEX1, AtHEX2, and AtHEX3, corresponding to reading frames At1g65590, At3g55260, and At1g05590). Based on homology, the Caenorhabditis HEX-1 and all three Arabidopsis enzymes are members of the same sub-family as the aforementioned Drosophila fused lobes enzyme but either act as chitotriosidases or non-specifically remove N-acetylglucosamine from both N-glycan antennae. The other four Caenorhabditis enzymes are members of a distinct sub-family; nevertheless, two of these enzymes displayed the same alpha1,3-antennal specificity as the fused lobes enzyme. Furthermore, a deletion of part of the Caenorhabditis hex-2 gene drastically reduces the native N-glycan-specific hexosaminidase activity in mutant worm extracts and results in a shift in the N-glycan profile, which is a demonstration of its in vivo enzymatic relevance. Based on these data, it is hypothesized that the genetic origin of paucimannosidic glycans in nematodes, plants, and insects involves highly divergent members of the same hexosaminidase gene family." @default.
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• W2015304433 date "2007-09-01" @default.
• W2015304433 modified "2023-10-17" @default.
• W2015304433 title "Biosynthesis of Truncated N-Linked Oligosaccharides Results from Non-orthologous Hexosaminidase-mediated Mechanisms in Nematodes, Plants, and Insects" @default.
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• W2015304433 cites W1501951324 @default.
• W2015304433 cites W1506660474 @default.
• W2015304433 cites W1533739152 @default.
• W2015304433 cites W1535201878 @default.
• W2015304433 cites W1591752816 @default.
• W2015304433 cites W1595421335 @default.
• W2015304433 cites W1960053061 @default.
• W2015304433 cites W1963592957 @default.
• W2015304433 cites W1966711413 @default.
• W2015304433 cites W1970361135 @default.
• W2015304433 cites W1970908974 @default.
• W2015304433 cites W1973231543 @default.
• W2015304433 cites W1975759007 @default.
• W2015304433 cites W1976830636 @default.
• W2015304433 cites W1977937848 @default.
• W2015304433 cites W1979106372 @default.
• W2015304433 cites W1979839979 @default.
• W2015304433 cites W1982060528 @default.
• W2015304433 cites W1983792126 @default.
• W2015304433 cites W1992877890 @default.
• W2015304433 cites W1996487921 @default.
• W2015304433 cites W1998555481 @default.
• W2015304433 cites W1999858285 @default.
• W2015304433 cites W1999972142 @default.
• W2015304433 cites W2000646355 @default.
• W2015304433 cites W2001084930 @default.
• W2015304433 cites W2009598363 @default.
• W2015304433 cites W2011006472 @default.
• W2015304433 cites W2011452349 @default.
• W2015304433 cites W2020021348 @default.
• W2015304433 cites W2025611972 @default.
• W2015304433 cites W2029075814 @default.
• W2015304433 cites W2029327065 @default.
• W2015304433 cites W2031894550 @default.
• W2015304433 cites W2035565243 @default.
• W2015304433 cites W2038777011 @default.
• W2015304433 cites W2045114633 @default.
• W2015304433 cites W2045966322 @default.
• W2015304433 cites W2046902274 @default.
• W2015304433 cites W2051759572 @default.
• W2015304433 cites W2057463431 @default.
• W2015304433 cites W2061891609 @default.
• W2015304433 cites W2063024363 @default.
• W2015304433 cites W2063819070 @default.
• W2015304433 cites W2069195710 @default.
• W2015304433 cites W2072131757 @default.
• W2015304433 cites W2073285709 @default.
• W2015304433 cites W2080340512 @default.
• W2015304433 cites W2084694430 @default.
• W2015304433 cites W2084841362 @default.
• W2015304433 cites W2084895800 @default.
• W2015304433 cites W2085529614 @default.
• W2015304433 cites W2100006724 @default.
• W2015304433 cites W2101330331 @default.
• W2015304433 cites W2102389229 @default.
• W2015304433 cites W2105955533 @default.
• W2015304433 cites W2108122020 @default.
• W2015304433 cites W2111812892 @default.
• W2015304433 cites W2117025282 @default.
• W2015304433 cites W2126684687 @default.
• W2015304433 cites W2129050183 @default.
• W2015304433 cites W2131917762 @default.
• W2015304433 cites W2133912554 @default.
• W2015304433 cites W2134451511 @default.
• W2015304433 cites W2135931409 @default.
• W2015304433 cites W2138537891 @default.
• W2015304433 cites W2152708819 @default.
• W2015304433 cites W2153665389 @default.
• W2015304433 cites W2159050517 @default.
• W2015304433 cites W2167407713 @default.
• W2015304433 cites W2171165822 @default.
• W2015304433 cites W283753259 @default.
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• W2015304433 doi "https://doi.org/10.1074/jbc.m704235200" @default.
• W2015304433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2850174" @default.
• W2015304433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17636254" @default.
• W2015304433 hasPublicationYear "2007" @default.
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