FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015304722> ?p ?o ?g. }

• W2015304722 endingPage "516" @default.
• W2015304722 startingPage "510" @default.
• W2015304722 abstract "Goals To evaluate the proportion of patients with histologic evidence of active liver disease (HEALD) who have chronic hepatitis B (CHB) and normal/minimally elevated serum alanine aminotransferase (ALT). Sub-analysis was performed to determine whether HEALD based upon liver biopsy better correlates with ALT using modified ALT (30 men/19 women) upper limit of normal (ULN) criteria compared with local conventional laboratory. Background There are limited data on CHB with normal range ALT (NRALT). We designed a study to evaluate histologic damage in this cohort of patients. Study A retrospective, multicenter study evaluated CHB patients with normal/minimally elevated ALT [≤1.2 × ULN (hepatitis B e antigen positive) or ≤1.5 × ULN (hepatitis B e antigen negative)]. Liver biopsy specimens were reviewed by an independent histopathologist. HEALD was defined as Knodell necroinflammatory score greater than 5 and Ishak fibrosis stage greater than 1. Results Forty-five patients met criteria: median age of 40 years; 51% males; 73% Asian; and 67% hepatitis B e antigen negative. Median hepatitis B virus DNA was 6.04 log10 copies/mL, aspartate aminotransferase (AST) 30 IU/L, and ALT 42 IU/L; and 40% of the patients had ALT greater than ULN. Overall, 20% had HEALD and among patients with NRALT, 4 of 27 (15%) and 0 of 5 (0%) had HEALD through conventional or modified ALT ULN, respectively. Conclusions One fifth of patients with CHB and normal/minimally elevated ALT had HEALD. Among the subset of patients with NRALT, 15% (4 of 27) had HEALD when using conventional laboratory compared with 0% (0 of 5) patients by modified ALT ULN criteria. Use of the modified ALT ULN will likely improve accuracy in identifying patients who may have HEALD compared with conventional laboratory ULN." @default.
• W2015304722 created "2016-06-24" @default.
• W2015304722 creator A5010968373 @default.
• W2015304722 creator A5024470010 @default.
• W2015304722 creator A5043116924 @default.
• W2015304722 creator A5043581009 @default.
• W2015304722 creator A5047152309 @default.
• W2015304722 creator A5050079986 @default.
• W2015304722 creator A5058938800 @default.
• W2015304722 creator A5063161613 @default.
• W2015304722 creator A5067379174 @default.
• W2015304722 creator A5070467866 @default.
• W2015304722 creator A5091028785 @default.
• W2015304722 date "2010-08-01" @default.
• W2015304722 modified "2023-10-03" @default.
• W2015304722 title "Histologic Evidence of Active Liver Injury in Chronic Hepatitis B Patients With Normal Range or Minimally Elevated Alanine Aminotransferase Levels" @default.
• W2015304722 cites W1991982625 @default.
• W2015304722 cites W2039198180 @default.
• W2015304722 cites W2064621848 @default.
• W2015304722 cites W2071337588 @default.
• W2015304722 cites W2071805414 @default.
• W2015304722 cites W2116460737 @default.
• W2015304722 cites W2133195866 @default.
• W2015304722 cites W2135386419 @default.
• W2015304722 cites W2154661593 @default.
• W2015304722 cites W2156015715 @default.
• W2015304722 cites W2161280033 @default.
• W2015304722 cites W2167596859 @default.
• W2015304722 cites W2170244859 @default.
• W2015304722 cites W2170897170 @default.
• W2015304722 cites W2393327590 @default.
• W2015304722 doi "https://doi.org/10.1097/mcg.0b013e3181d34c65" @default.
• W2015304722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20179614" @default.
• W2015304722 hasPublicationYear "2010" @default.
• W2015304722 type Work @default.
• W2015304722 sameAs 2015304722 @default.
• W2015304722 citedByCount "15" @default.
• W2015304722 countsByYear W20153047222012 @default.
• W2015304722 countsByYear W20153047222013 @default.
• W2015304722 countsByYear W20153047222014 @default.
• W2015304722 countsByYear W20153047222015 @default.
• W2015304722 countsByYear W20153047222018 @default.
• W2015304722 countsByYear W20153047222022 @default.
• W2015304722 crossrefType "journal-article" @default.
• W2015304722 hasAuthorship W2015304722A5010968373 @default.
• W2015304722 hasAuthorship W2015304722A5024470010 @default.
• W2015304722 hasAuthorship W2015304722A5043116924 @default.
• W2015304722 hasAuthorship W2015304722A5043581009 @default.
• W2015304722 hasAuthorship W2015304722A5047152309 @default.
• W2015304722 hasAuthorship W2015304722A5050079986 @default.
• W2015304722 hasAuthorship W2015304722A5058938800 @default.
• W2015304722 hasAuthorship W2015304722A5063161613 @default.
• W2015304722 hasAuthorship W2015304722A5067379174 @default.
• W2015304722 hasAuthorship W2015304722A5070467866 @default.
• W2015304722 hasAuthorship W2015304722A5091028785 @default.
• W2015304722 hasConcept C126322002 @default.
• W2015304722 hasConcept C167135981 @default.
• W2015304722 hasConcept C2775934546 @default.
• W2015304722 hasConcept C2776029263 @default.
• W2015304722 hasConcept C2777075537 @default.
• W2015304722 hasConcept C2777382497 @default.
• W2015304722 hasConcept C2777766500 @default.
• W2015304722 hasConcept C2778606649 @default.
• W2015304722 hasConcept C2992872382 @default.
• W2015304722 hasConcept C71924100 @default.
• W2015304722 hasConcept C72563966 @default.
• W2015304722 hasConcept C90924648 @default.
• W2015304722 hasConceptScore W2015304722C126322002 @default.
• W2015304722 hasConceptScore W2015304722C167135981 @default.
• W2015304722 hasConceptScore W2015304722C2775934546 @default.
• W2015304722 hasConceptScore W2015304722C2776029263 @default.
• W2015304722 hasConceptScore W2015304722C2777075537 @default.
• W2015304722 hasConceptScore W2015304722C2777382497 @default.
• W2015304722 hasConceptScore W2015304722C2777766500 @default.
• W2015304722 hasConceptScore W2015304722C2778606649 @default.
• W2015304722 hasConceptScore W2015304722C2992872382 @default.
• W2015304722 hasConceptScore W2015304722C71924100 @default.
• W2015304722 hasConceptScore W2015304722C72563966 @default.
• W2015304722 hasConceptScore W2015304722C90924648 @default.
• W2015304722 hasIssue "7" @default.
• W2015304722 hasLocation W20153047221 @default.
• W2015304722 hasLocation W20153047222 @default.
• W2015304722 hasOpenAccess W2015304722 @default.
• W2015304722 hasPrimaryLocation W20153047221 @default.
• W2015304722 hasRelatedWork W1516512747 @default.
• W2015304722 hasRelatedWork W1995787934 @default.
• W2015304722 hasRelatedWork W2078688345 @default.
• W2015304722 hasRelatedWork W2149521544 @default.
• W2015304722 hasRelatedWork W2376817579 @default.
• W2015304722 hasRelatedWork W2898185941 @default.
• W2015304722 hasRelatedWork W3031563716 @default.
• W2015304722 hasRelatedWork W307921490 @default.
• W2015304722 hasRelatedWork W3210660536 @default.
• W2015304722 hasRelatedWork W4317861042 @default.
• W2015304722 hasVolume "44" @default.
• W2015304722 isParatext "false" @default.
• W2015304722 isRetracted "false" @default.
• W2015304722 magId "2015304722" @default.

• next