Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015306148> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2015306148 endingPage "493" @default.
- W2015306148 startingPage "489" @default.
- W2015306148 abstract "Single cell suspensions of murine epidermal cells were studied for the generation of leukotrienes (LTs), using in vitro bioassays for chemotaxis, reverse-phase high-pressure liquid chromatography (HPLC), and radioimmunoassays (RIAs). A combination of arachidonic acid (AA) at 10-3-10-;4 M with the calcium ionophore A 23187 at 5 × 10-6 M was the most potent stimulus, causing release of LTs within 10–30 mm. Other stimuli, like the N-formyl-methionyl- leucyl-phenylalanine, at 10-7 M and bradykinin at 10-3 M, were less effective, and the tumor promotor phorbol-myristate-acetate (10-5-10-8 M) caused no release at all. AA induced release at cytotoxic concentrations, but the other stimuli did not, and keratinocytes from different body regions were equally good sources of the LTs. In vivo or in vitro pretreatment of keratinocytes with UV radiation did not alter spontaneous or stimulated secretion of LTs, while pretreatment of cells with Ia, but not with Thy-1, monoclonal antibodies caused a moderate decrease of release. Analyses by HPLC indicated the release of 20-OH-LTB4 in addition to LTB4 in cell supernatants. Murine keratinocytes and epidermal dendritic cells serve therefore as a source of chemotactic leukotrienes after appropriate in vitro stimulation with agents that are known to play a role in cutaneous inflammation." @default.
- W2015306148 created "2016-06-24" @default.
- W2015306148 creator A5009917736 @default.
- W2015306148 creator A5034311067 @default.
- W2015306148 creator A5068177884 @default.
- W2015306148 date "1986-10-01" @default.
- W2015306148 modified "2023-09-24" @default.
- W2015306148 title "In Vitro Generation of Chemotactic Leukotrienes from Unfractionated Murine Epidermal Cells" @default.
- W2015306148 cites W1489871342 @default.
- W2015306148 cites W1573558348 @default.
- W2015306148 cites W1602588405 @default.
- W2015306148 cites W1981086802 @default.
- W2015306148 cites W1992612062 @default.
- W2015306148 cites W2000026291 @default.
- W2015306148 cites W2000098150 @default.
- W2015306148 cites W2001897850 @default.
- W2015306148 cites W2004132973 @default.
- W2015306148 cites W2016017319 @default.
- W2015306148 cites W2021827311 @default.
- W2015306148 cites W2023213942 @default.
- W2015306148 cites W2025346393 @default.
- W2015306148 cites W2032788608 @default.
- W2015306148 cites W2038468255 @default.
- W2015306148 cites W2061829983 @default.
- W2015306148 cites W2069343229 @default.
- W2015306148 cites W2069959821 @default.
- W2015306148 cites W2075149823 @default.
- W2015306148 cites W2075460821 @default.
- W2015306148 cites W2076658850 @default.
- W2015306148 cites W2083258588 @default.
- W2015306148 cites W2090197359 @default.
- W2015306148 doi "https://doi.org/10.1111/1523-1747.ep12455554" @default.
- W2015306148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3020131" @default.
- W2015306148 hasPublicationYear "1986" @default.
- W2015306148 type Work @default.
- W2015306148 sameAs 2015306148 @default.
- W2015306148 citedByCount "7" @default.
- W2015306148 crossrefType "journal-article" @default.
- W2015306148 hasAuthorship W2015306148A5009917736 @default.
- W2015306148 hasAuthorship W2015306148A5034311067 @default.
- W2015306148 hasAuthorship W2015306148A5068177884 @default.
- W2015306148 hasConcept C153911025 @default.
- W2015306148 hasConcept C170493617 @default.
- W2015306148 hasConcept C181199279 @default.
- W2015306148 hasConcept C185592680 @default.
- W2015306148 hasConcept C202751555 @default.
- W2015306148 hasConcept C203014093 @default.
- W2015306148 hasConcept C2776685179 @default.
- W2015306148 hasConcept C2776914184 @default.
- W2015306148 hasConcept C2778078955 @default.
- W2015306148 hasConcept C2779591629 @default.
- W2015306148 hasConcept C2779866169 @default.
- W2015306148 hasConcept C54166955 @default.
- W2015306148 hasConcept C54355233 @default.
- W2015306148 hasConcept C55493867 @default.
- W2015306148 hasConcept C81885089 @default.
- W2015306148 hasConcept C86803240 @default.
- W2015306148 hasConcept C98274493 @default.
- W2015306148 hasConceptScore W2015306148C153911025 @default.
- W2015306148 hasConceptScore W2015306148C170493617 @default.
- W2015306148 hasConceptScore W2015306148C181199279 @default.
- W2015306148 hasConceptScore W2015306148C185592680 @default.
- W2015306148 hasConceptScore W2015306148C202751555 @default.
- W2015306148 hasConceptScore W2015306148C203014093 @default.
- W2015306148 hasConceptScore W2015306148C2776685179 @default.
- W2015306148 hasConceptScore W2015306148C2776914184 @default.
- W2015306148 hasConceptScore W2015306148C2778078955 @default.
- W2015306148 hasConceptScore W2015306148C2779591629 @default.
- W2015306148 hasConceptScore W2015306148C2779866169 @default.
- W2015306148 hasConceptScore W2015306148C54166955 @default.
- W2015306148 hasConceptScore W2015306148C54355233 @default.
- W2015306148 hasConceptScore W2015306148C55493867 @default.
- W2015306148 hasConceptScore W2015306148C81885089 @default.
- W2015306148 hasConceptScore W2015306148C86803240 @default.
- W2015306148 hasConceptScore W2015306148C98274493 @default.
- W2015306148 hasIssue "4" @default.
- W2015306148 hasLocation W20153061481 @default.
- W2015306148 hasLocation W20153061482 @default.
- W2015306148 hasOpenAccess W2015306148 @default.
- W2015306148 hasPrimaryLocation W20153061481 @default.
- W2015306148 hasRelatedWork W153197441 @default.
- W2015306148 hasRelatedWork W1972368094 @default.
- W2015306148 hasRelatedWork W2004916327 @default.
- W2015306148 hasRelatedWork W2011471403 @default.
- W2015306148 hasRelatedWork W2032525113 @default.
- W2015306148 hasRelatedWork W2061829983 @default.
- W2015306148 hasRelatedWork W2066225691 @default.
- W2015306148 hasRelatedWork W2417415454 @default.
- W2015306148 hasRelatedWork W964659970 @default.
- W2015306148 hasRelatedWork W1968594405 @default.
- W2015306148 hasVolume "87" @default.
- W2015306148 isParatext "false" @default.
- W2015306148 isRetracted "false" @default.
- W2015306148 magId "2015306148" @default.
- W2015306148 workType "article" @default.