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- W2015306208 abstract "Cerebral ischaemia-reperfusion injury is associated with an inflammatory response, with contributions from leucocytes and microglia. Formation of free radicals and nitric oxide contributes to the development of cerebral infarction and of the neurological deficit that follows transient focal ischaemia. The circulating and cerebral renin-angiotensin systems contribute, via stimulation of the angiotensin II (Ang II) types 1 (AT1) and 2 receptors, to the initiation or progression of inflammatory processes, and blockade of AT1-receptors prevents irreversible tissue injury and improves outcome from stroke in animal experiments. Such cerebral protection can be achieved even when treatment is initiated hours after established reperfusion. Blockade of AT1-receptors also reduces the incidence of stroke and cardiovascular mortality associated with stroke in patients; however, the mechanisms underlying the prevention of stroke by AT1-receptor blockade in patients remain to be elucidated. In this review we summarize the existing experimental and clinical data demonstrating that the renin-angiotensin system contributes to the inflammation and subsequent irreversible injury after cerebral ischaemia-reperfusion. We conclude that AT1-receptor blockade reduces cerebral ischaemia-reperfusion injury in part by attenuating inflammatory processes." @default.
- W2015306208 created "2016-06-24" @default.
- W2015306208 creator A5000925780 @default.
- W2015306208 creator A5076082024 @default.
- W2015306208 date "2006-03-01" @default.
- W2015306208 modified "2023-10-10" @default.
- W2015306208 title "Angiotensin II type 1 receptors in cerebral ischaemia-reperfusion: initiation of inflammation" @default.
- W2015306208 cites W1510592624 @default.
- W2015306208 cites W1635047156 @default.
- W2015306208 cites W1667686291 @default.
- W2015306208 cites W1968228068 @default.
- W2015306208 cites W1974131493 @default.
- W2015306208 cites W1974957881 @default.
- W2015306208 cites W1979520552 @default.
- W2015306208 cites W1979523972 @default.
- W2015306208 cites W1980322487 @default.
- W2015306208 cites W1982489164 @default.
- W2015306208 cites W1988206467 @default.
- W2015306208 cites W1989357657 @default.
- W2015306208 cites W1993814619 @default.
- W2015306208 cites W1995498713 @default.
- W2015306208 cites W1998654183 @default.
- W2015306208 cites W2003300261 @default.
- W2015306208 cites W2004930517 @default.
- W2015306208 cites W2009274825 @default.
- W2015306208 cites W2017773490 @default.
- W2015306208 cites W2018360662 @default.
- W2015306208 cites W2018784274 @default.
- W2015306208 cites W2020770604 @default.
- W2015306208 cites W2021167391 @default.
- W2015306208 cites W2027589113 @default.
- W2015306208 cites W2027718668 @default.
- W2015306208 cites W2028877394 @default.
- W2015306208 cites W2029479814 @default.
- W2015306208 cites W2031967677 @default.
- W2015306208 cites W2032835804 @default.
- W2015306208 cites W2035336513 @default.
- W2015306208 cites W2036695904 @default.
- W2015306208 cites W2040358871 @default.
- W2015306208 cites W2042095676 @default.
- W2015306208 cites W2042678930 @default.
- W2015306208 cites W2044033947 @default.
- W2015306208 cites W2050797367 @default.
- W2015306208 cites W2050875736 @default.
- W2015306208 cites W2051694729 @default.
- W2015306208 cites W2053649709 @default.
- W2015306208 cites W2054888039 @default.
- W2015306208 cites W2055088294 @default.
- W2015306208 cites W2055505947 @default.
- W2015306208 cites W2055629572 @default.
- W2015306208 cites W2057150555 @default.
- W2015306208 cites W2062212798 @default.
- W2015306208 cites W2066613248 @default.
- W2015306208 cites W2069797303 @default.
- W2015306208 cites W2070655938 @default.
- W2015306208 cites W2071248867 @default.
- W2015306208 cites W2071432618 @default.
- W2015306208 cites W2072749612 @default.
- W2015306208 cites W2074187719 @default.
- W2015306208 cites W2075965178 @default.
- W2015306208 cites W2081355091 @default.
- W2015306208 cites W2082054081 @default.
- W2015306208 cites W2085112247 @default.
- W2015306208 cites W2086199925 @default.
- W2015306208 cites W2088230441 @default.
- W2015306208 cites W2088557737 @default.
- W2015306208 cites W2090806477 @default.
- W2015306208 cites W2093346437 @default.
- W2015306208 cites W2094961474 @default.
- W2015306208 cites W2097741198 @default.
- W2015306208 cites W2098429613 @default.
- W2015306208 cites W2100249813 @default.
- W2015306208 cites W2101736298 @default.
- W2015306208 cites W2113554954 @default.
- W2015306208 cites W2117104323 @default.
- W2015306208 cites W2121219041 @default.
- W2015306208 cites W2121682032 @default.
- W2015306208 cites W2122070039 @default.
- W2015306208 cites W2127091487 @default.
- W2015306208 cites W2142541950 @default.
- W2015306208 cites W2144300398 @default.
- W2015306208 cites W2144918294 @default.
- W2015306208 cites W2147678042 @default.
- W2015306208 cites W2150445521 @default.
- W2015306208 cites W2151773852 @default.
- W2015306208 cites W2166342281 @default.
- W2015306208 cites W2166781237 @default.
- W2015306208 cites W2168322315 @default.
- W2015306208 cites W2182230456 @default.
- W2015306208 cites W2317227939 @default.
- W2015306208 cites W2474196319 @default.
- W2015306208 doi "https://doi.org/10.1097/01.hjh.0000220417.01397.6a" @default.
- W2015306208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16601565" @default.
- W2015306208 hasPublicationYear "2006" @default.
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