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- W2015307002 abstract "A new series of 1β-methyl carbapenems possessing a 6,7-disubstituted imidazo[5,1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus was prepared, and their activities against methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. First, a benzyl moiety was introduced at the C-6 position of imidazo[5,1-b]thiazole attached to the carbapenem. These benzylated molecules showed potent anti-MRSA activity, but poor water solubility. In order to overcome this drawback, we designed and synthesized di- and tricationic carbapenems and finally discovered a novel carbapenem (15i), which exhibited excellent anti-MRSA activity and good water solubility." @default.
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- W2015307002 date "2009-01-01" @default.
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- W2015307002 title "Synthesis of novel di- and tricationic carbapenems with potent anti-MRSA activity" @default.
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- W2015307002 doi "https://doi.org/10.1016/j.bmcl.2008.11.039" @default.
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