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- W2015307784 abstract "GPR30, now named GPER1 (G protein-coupled estrogen receptor1) or GPER here, was first identified as an orphan 7-transmembrane G protein-coupled receptor by multiple laboratories using either homology cloning or differential expression and subsequently shown to be required for estrogen-mediated signaling in certain cancer cells. The actions of estrogen are extensive in the body and are thought to be mediated predominantly by classical nuclear estrogen receptors that act as transcription factors/regulators. Nevertheless, certain aspects of estrogen function remain incompatible with the generally accepted mechanisms of classical estrogen receptor action. Many recent studies have revealed that GPER contributes to some of the actions of estrogen, including rapid signaling events and rapid transcriptional activation. With the introduction of GPER-selective ligands and GPER knockout mice, the functions of GPER are becoming more clearly defined. In many cases, there appears to be a complex interplay between the two receptor systems, suggesting that estrogen-mediated physiological responses may be mediated by either receptor or a combination of both receptor types, with important medical implications." @default.
- W2015307784 created "2016-06-24" @default.
- W2015307784 creator A5060993179 @default.
- W2015307784 creator A5086398434 @default.
- W2015307784 date "2009-09-01" @default.
- W2015307784 modified "2023-09-26" @default.
- W2015307784 title "Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER" @default.
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