Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015307962> ?p ?o ?g. }
- W2015307962 endingPage "e1000381" @default.
- W2015307962 startingPage "e1000381" @default.
- W2015307962 abstract "Intracellular parasites of the genus Leishmania generate severe diseases in humans, which are associated with a failure of the infected host to induce a protective interferon γ (IFNγ)-mediated immune response. We tested the role of the JAK/STAT1 signaling pathway in Leishmania pathogenesis by utilizing knockout mice lacking the signal transducer and activator of transcription 1 (Stat1) and derived macrophages. Unexpectedly, infection of Stat1-deficient macrophages in vitro with promastigotes from Leishmania major and attenuated LPG1 knockout mutants (lpg−) specifically lacking lipophosphoglycan (LPG) resulted in a twofold increased intracellular growth, which was independent of IFNγ and associated with a substantial increase in phagosomal pH. Phagosomes in Stat1−/− macrophages showed normal maturation as judged by the accumulation of the lysosomal marker protein rab7, and provided normal vATPase activity, but were defective in the anion conductive pathway required for full vesicular acidification. Our results suggest a role of acidic pH in the control of intracellular Leishmania growth early during infection and identify for the first time an unexpected role of Stat1 in natural anti-microbial resistance independent from its function as IFNγ-induced signal transducer. This novel Stat1 function may have important implications to studies of other pathogens, as the acidic phagolysosomal pH plays an important role in antigen processing and the uncoating process of many viruses." @default.
- W2015307962 created "2016-06-24" @default.
- W2015307962 creator A5007063454 @default.
- W2015307962 creator A5056034482 @default.
- W2015307962 creator A5064492946 @default.
- W2015307962 creator A5086001447 @default.
- W2015307962 date "2009-04-17" @default.
- W2015307962 modified "2023-09-26" @default.
- W2015307962 title "A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major" @default.
- W2015307962 cites W1588532479 @default.
- W2015307962 cites W1910381980 @default.
- W2015307962 cites W1968292510 @default.
- W2015307962 cites W1968414769 @default.
- W2015307962 cites W1980969503 @default.
- W2015307962 cites W1986304462 @default.
- W2015307962 cites W1990802251 @default.
- W2015307962 cites W1990821898 @default.
- W2015307962 cites W1995056769 @default.
- W2015307962 cites W1995651410 @default.
- W2015307962 cites W2002204067 @default.
- W2015307962 cites W2003375160 @default.
- W2015307962 cites W2004186508 @default.
- W2015307962 cites W2006393800 @default.
- W2015307962 cites W2018138443 @default.
- W2015307962 cites W2027109238 @default.
- W2015307962 cites W2034083035 @default.
- W2015307962 cites W2035033919 @default.
- W2015307962 cites W2036537260 @default.
- W2015307962 cites W2036742255 @default.
- W2015307962 cites W2039070421 @default.
- W2015307962 cites W2040984444 @default.
- W2015307962 cites W2042293477 @default.
- W2015307962 cites W2050432550 @default.
- W2015307962 cites W2052401601 @default.
- W2015307962 cites W2058003707 @default.
- W2015307962 cites W2063504630 @default.
- W2015307962 cites W2074834150 @default.
- W2015307962 cites W2076943891 @default.
- W2015307962 cites W2079270852 @default.
- W2015307962 cites W2079357798 @default.
- W2015307962 cites W2083802827 @default.
- W2015307962 cites W2084128540 @default.
- W2015307962 cites W2085384499 @default.
- W2015307962 cites W2086382728 @default.
- W2015307962 cites W2090217849 @default.
- W2015307962 cites W2093392246 @default.
- W2015307962 cites W2103565638 @default.
- W2015307962 cites W2104416424 @default.
- W2015307962 cites W2122506044 @default.
- W2015307962 cites W2129222867 @default.
- W2015307962 cites W2130709215 @default.
- W2015307962 cites W2130967505 @default.
- W2015307962 cites W2132376182 @default.
- W2015307962 cites W2132617233 @default.
- W2015307962 cites W2135911291 @default.
- W2015307962 cites W2138974828 @default.
- W2015307962 cites W2142746235 @default.
- W2015307962 cites W2147803180 @default.
- W2015307962 cites W2151440062 @default.
- W2015307962 cites W2152234597 @default.
- W2015307962 cites W2153748987 @default.
- W2015307962 cites W2168930459 @default.
- W2015307962 cites W2169931949 @default.
- W2015307962 cites W2171821916 @default.
- W2015307962 cites W2188200025 @default.
- W2015307962 cites W2264999501 @default.
- W2015307962 cites W2331106694 @default.
- W2015307962 doi "https://doi.org/10.1371/journal.ppat.1000381" @default.
- W2015307962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663844" @default.
- W2015307962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19381261" @default.
- W2015307962 hasPublicationYear "2009" @default.
- W2015307962 type Work @default.
- W2015307962 sameAs 2015307962 @default.
- W2015307962 citedByCount "33" @default.
- W2015307962 countsByYear W20153079622012 @default.
- W2015307962 countsByYear W20153079622013 @default.
- W2015307962 countsByYear W20153079622014 @default.
- W2015307962 countsByYear W20153079622015 @default.
- W2015307962 countsByYear W20153079622016 @default.
- W2015307962 countsByYear W20153079622017 @default.
- W2015307962 countsByYear W20153079622018 @default.
- W2015307962 countsByYear W20153079622019 @default.
- W2015307962 countsByYear W20153079622020 @default.
- W2015307962 countsByYear W20153079622021 @default.
- W2015307962 countsByYear W20153079622022 @default.
- W2015307962 crossrefType "journal-article" @default.
- W2015307962 hasAuthorship W2015307962A5007063454 @default.
- W2015307962 hasAuthorship W2015307962A5056034482 @default.
- W2015307962 hasAuthorship W2015307962A5064492946 @default.
- W2015307962 hasAuthorship W2015307962A5086001447 @default.
- W2015307962 hasBestOaLocation W20153079621 @default.
- W2015307962 hasConcept C102747710 @default.
- W2015307962 hasConcept C136764020 @default.
- W2015307962 hasConcept C144382850 @default.
- W2015307962 hasConcept C153726182 @default.
- W2015307962 hasConcept C159047783 @default.
- W2015307962 hasConcept C161478664 @default.
- W2015307962 hasConcept C171958077 @default.