Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015309063> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2015309063 endingPage "153" @default.
- W2015309063 startingPage "147" @default.
- W2015309063 abstract "IV valproate may be given to patients requiring rapid elevation of serum valproate or for patients unable to take oral medication. Previously we established the loading dose of IV valproate needed to achieve serum concentrations of >100 ug/ml. This study evaluated the safety of rapid infusion of valproate to achieve high therapeutic levels. Twenty-four infusions of IV valproate were carried out electively in twenty-one patients with epilepsy (ages 2–54 years). The dose ranged from 21–28 mg/kg (mean 24.2 mg/kg). Target infusion rates were 3 or 6 mg/kg per min, yielding an infusion duration of 4.17 or 8.34 min. ECG was monitored; blood pressure was measured before and after infusion. Post infusion serum valproate concentrations were 64–204.1 ug/ml (mean 132.6). There were no significant changes in blood pressure and no ECG abnormalities observed. Transient pain occurred at the site of injection in five patients, associated with redness in two. This appeared to related to the concentration of valproic acid in the infusion fluid. We conclude that a loading dose of IV valproate can be administered safely and rapidly. This finding enables further studies evaluating IV valproate as a non-sedative anticonvulsant in the management of status epilepticus." @default.
- W2015309063 created "2016-06-24" @default.
- W2015309063 creator A5032129336 @default.
- W2015309063 creator A5065643106 @default.
- W2015309063 date "1999-06-01" @default.
- W2015309063 modified "2023-10-17" @default.
- W2015309063 title "Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients" @default.
- W2015309063 cites W1995998505 @default.
- W2015309063 cites W1998508222 @default.
- W2015309063 cites W1998893465 @default.
- W2015309063 cites W2001028181 @default.
- W2015309063 cites W2005459258 @default.
- W2015309063 cites W2016152924 @default.
- W2015309063 cites W2155030514 @default.
- W2015309063 cites W2214901550 @default.
- W2015309063 cites W2398504645 @default.
- W2015309063 cites W4241145278 @default.
- W2015309063 doi "https://doi.org/10.1016/s0920-1211(99)00005-4" @default.
- W2015309063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10372567" @default.
- W2015309063 hasPublicationYear "1999" @default.
- W2015309063 type Work @default.
- W2015309063 sameAs 2015309063 @default.
- W2015309063 citedByCount "114" @default.
- W2015309063 countsByYear W20153090632012 @default.
- W2015309063 countsByYear W20153090632013 @default.
- W2015309063 countsByYear W20153090632014 @default.
- W2015309063 countsByYear W20153090632015 @default.
- W2015309063 countsByYear W20153090632016 @default.
- W2015309063 countsByYear W20153090632017 @default.
- W2015309063 countsByYear W20153090632018 @default.
- W2015309063 countsByYear W20153090632019 @default.
- W2015309063 countsByYear W20153090632020 @default.
- W2015309063 countsByYear W20153090632021 @default.
- W2015309063 countsByYear W20153090632022 @default.
- W2015309063 crossrefType "journal-article" @default.
- W2015309063 hasAuthorship W2015309063A5032129336 @default.
- W2015309063 hasAuthorship W2015309063A5065643106 @default.
- W2015309063 hasConcept C118552586 @default.
- W2015309063 hasConcept C126322002 @default.
- W2015309063 hasConcept C2775858608 @default.
- W2015309063 hasConcept C2777172819 @default.
- W2015309063 hasConcept C2777341932 @default.
- W2015309063 hasConcept C2777602617 @default.
- W2015309063 hasConcept C2778186239 @default.
- W2015309063 hasConcept C35294091 @default.
- W2015309063 hasConcept C42219234 @default.
- W2015309063 hasConcept C71924100 @default.
- W2015309063 hasConcept C84393581 @default.
- W2015309063 hasConceptScore W2015309063C118552586 @default.
- W2015309063 hasConceptScore W2015309063C126322002 @default.
- W2015309063 hasConceptScore W2015309063C2775858608 @default.
- W2015309063 hasConceptScore W2015309063C2777172819 @default.
- W2015309063 hasConceptScore W2015309063C2777341932 @default.
- W2015309063 hasConceptScore W2015309063C2777602617 @default.
- W2015309063 hasConceptScore W2015309063C2778186239 @default.
- W2015309063 hasConceptScore W2015309063C35294091 @default.
- W2015309063 hasConceptScore W2015309063C42219234 @default.
- W2015309063 hasConceptScore W2015309063C71924100 @default.
- W2015309063 hasConceptScore W2015309063C84393581 @default.
- W2015309063 hasIssue "2" @default.
- W2015309063 hasLocation W20153090631 @default.
- W2015309063 hasLocation W20153090632 @default.
- W2015309063 hasOpenAccess W2015309063 @default.
- W2015309063 hasPrimaryLocation W20153090631 @default.
- W2015309063 hasRelatedWork W1970354875 @default.
- W2015309063 hasRelatedWork W1983334633 @default.
- W2015309063 hasRelatedWork W1986055961 @default.
- W2015309063 hasRelatedWork W1993168621 @default.
- W2015309063 hasRelatedWork W2062344350 @default.
- W2015309063 hasRelatedWork W2094794091 @default.
- W2015309063 hasRelatedWork W2472926793 @default.
- W2015309063 hasRelatedWork W3102864887 @default.
- W2015309063 hasRelatedWork W2069046240 @default.
- W2015309063 hasRelatedWork W2412380707 @default.
- W2015309063 hasVolume "35" @default.
- W2015309063 isParatext "false" @default.
- W2015309063 isRetracted "false" @default.
- W2015309063 magId "2015309063" @default.
- W2015309063 workType "article" @default.