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- W2015311906 abstract "A sensitive assay for the determination of N,N',N-triethylenethiophosphoramide (thioTEPA) and its metabolite N,N',N-triethylenephosphoramide (TEPA) in micro-volumes human plasma and urine has been developed. ThioTEPA and TEPA were analysed using gas chromatography with selective nitrogen-phosphorus detection or mass spectrometry after extraction with a mixture of 1-propanol-chloroform from the biological matrix. Diphenylamine was used as internal standard. The limit of detection was 1.5 ng/ml for thioTEPA and 2.5 ng/ml for TEPA, using 100 microl of biological sample; recoveries ranged between 70 and 90% and both accuracy and precision were less than 10%. Linearity was accomplished in the range of 10-1000 ng/ml for plasma and 100-10000 ng/ml for urine using thermionic nitrogen-phosphorus detection. With mass spectrometry a linear range of 100-25000 ng/ml TEPA in plasma or urine was obtained. For thioTEPA a second-order polynomial function describes the relationship between the analyte concentration in the range of 500-25000 ng/ml and detection response. TEPA proved to be stable in plasma and urine for at least 10 weeks at -80 degrees C. ThioTEPA and TEPA plasma concentrations of two patients treated with thioTEPA are presented demonstrating the applicability of the assay for clinical samples." @default.
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- W2015311906 date "1998-11-01" @default.
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- W2015311906 title "Determination of N,N′,N″-triethylenethiophosphoramide and its active metabolite N,N′,N″-triethylenephosphoramide in plasma and urine using capillary gas chromatography" @default.
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- W2015311906 doi "https://doi.org/10.1016/s0378-4347(98)00381-8" @default.
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