FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015313445> ?p ?o ?g. }

• W2015313445 endingPage "2300" @default.
• W2015313445 startingPage "2290" @default.
• W2015313445 abstract "In normal mouse mammary gland, the mitogenic action of progesterone (P) is mediated by two P receptor (PR) isoforms, PRA and PRB. PRA is predominantly expressed in the adult virgin, and PRB is predominantly expressed during pregnancy. To investigate hormonal regulation of PR isoform expression and isoform-specific functions in vivo, adult ovariectomized BALB/c mice were treated for 3, 5, or 10 d with estrogen (E), P, or estrogen plus progesterone (E+P). Using an immunohistochemical approach with isoform-specific antibodies, we investigated hormonal regulation of PRA and PRB and their functional roles in proliferation and morphogenesis. Significant E-induced proliferation was only observed after 5 d at the distal tips of ducts; there was no sidebranching or alveologenesis. P induced proliferation that resulted in sidebranching and alveologenesis, but E+P treatment produced more proliferation sooner and more extensive sidebranching and alveologenesis. PRA levels were increased by E and decreased by P. Increased PRB levels were induced by treatment with P or E+P and coincided with the formation of alveoli. PRA was the predominant PR isoform expressed during sidebranching, and colocalization of PRA with 5-bromo-2′-deoxyuridine revealed that proliferation of PRA-positive and -negative cells was responsible for P-induced sidebranching. PRB was the predominant PR isoform expressed during alveologenesis, and colocalization of PRB with 5-bromo-2′-deoxyuridine showed that both PRB-positive and -negative cells proliferated during alveolar expansion. These results demonstrate different hormonal regulation of PRA and PRB levels in vivo and suggest that P can induce proliferation through either PRA or PRB via direct and paracrine mechanisms." @default.
• W2015313445 created "2016-06-24" @default.
• W2015313445 creator A5045100047 @default.
• W2015313445 creator A5070209902 @default.
• W2015313445 date "2007-05-01" @default.
• W2015313445 modified "2023-09-26" @default.
• W2015313445 title "Differential Hormonal Regulation and Function of Progesterone Receptor Isoforms in Normal Adult Mouse Mammary Gland" @default.
• W2015313445 cites W1239358504 @default.
• W2015313445 cites W1494693924 @default.
• W2015313445 cites W1569754307 @default.
• W2015313445 cites W1699139311 @default.
• W2015313445 cites W1965768287 @default.
• W2015313445 cites W1970078194 @default.
• W2015313445 cites W1988168602 @default.
• W2015313445 cites W2002509189 @default.
• W2015313445 cites W2004633183 @default.
• W2015313445 cites W2012904520 @default.
• W2015313445 cites W2022654115 @default.
• W2015313445 cites W2025995094 @default.
• W2015313445 cites W2030899358 @default.
• W2015313445 cites W2040541451 @default.
• W2015313445 cites W2042571781 @default.
• W2015313445 cites W2043278640 @default.
• W2015313445 cites W2050516070 @default.
• W2015313445 cites W2071590828 @default.
• W2015313445 cites W2103791567 @default.
• W2015313445 cites W2108219444 @default.
• W2015313445 cites W2156989552 @default.
• W2015313445 cites W2167098097 @default.
• W2015313445 cites W2412849637 @default.
• W2015313445 cites W2762697978 @default.
• W2015313445 doi "https://doi.org/10.1210/en.2006-1721" @default.
• W2015313445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17317767" @default.
• W2015313445 hasPublicationYear "2007" @default.
• W2015313445 type Work @default.
• W2015313445 sameAs 2015313445 @default.
• W2015313445 citedByCount "73" @default.
• W2015313445 countsByYear W20153134452012 @default.
• W2015313445 countsByYear W20153134452013 @default.
• W2015313445 countsByYear W20153134452014 @default.
• W2015313445 countsByYear W20153134452015 @default.
• W2015313445 countsByYear W20153134452016 @default.
• W2015313445 countsByYear W20153134452017 @default.
• W2015313445 countsByYear W20153134452018 @default.
• W2015313445 countsByYear W20153134452019 @default.
• W2015313445 countsByYear W20153134452020 @default.
• W2015313445 countsByYear W20153134452021 @default.
• W2015313445 crossrefType "journal-article" @default.
• W2015313445 hasAuthorship W2015313445A5045100047 @default.
• W2015313445 hasAuthorship W2015313445A5070209902 @default.
• W2015313445 hasConcept C104317684 @default.
• W2015313445 hasConcept C121608353 @default.
• W2015313445 hasConcept C126322002 @default.
• W2015313445 hasConcept C134018914 @default.
• W2015313445 hasConcept C16930146 @default.
• W2015313445 hasConcept C170493617 @default.
• W2015313445 hasConcept C204232928 @default.
• W2015313445 hasConcept C2777164284 @default.
• W2015313445 hasConcept C40209533 @default.
• W2015313445 hasConcept C530470458 @default.
• W2015313445 hasConcept C53345823 @default.
• W2015313445 hasConcept C55493867 @default.
• W2015313445 hasConcept C71924100 @default.
• W2015313445 hasConcept C84606932 @default.
• W2015313445 hasConcept C86803240 @default.
• W2015313445 hasConcept C95444343 @default.
• W2015313445 hasConcept C98717036 @default.
• W2015313445 hasConceptScore W2015313445C104317684 @default.
• W2015313445 hasConceptScore W2015313445C121608353 @default.
• W2015313445 hasConceptScore W2015313445C126322002 @default.
• W2015313445 hasConceptScore W2015313445C134018914 @default.
• W2015313445 hasConceptScore W2015313445C16930146 @default.
• W2015313445 hasConceptScore W2015313445C170493617 @default.
• W2015313445 hasConceptScore W2015313445C204232928 @default.
• W2015313445 hasConceptScore W2015313445C2777164284 @default.
• W2015313445 hasConceptScore W2015313445C40209533 @default.
• W2015313445 hasConceptScore W2015313445C530470458 @default.
• W2015313445 hasConceptScore W2015313445C53345823 @default.
• W2015313445 hasConceptScore W2015313445C55493867 @default.
• W2015313445 hasConceptScore W2015313445C71924100 @default.
• W2015313445 hasConceptScore W2015313445C84606932 @default.
• W2015313445 hasConceptScore W2015313445C86803240 @default.
• W2015313445 hasConceptScore W2015313445C95444343 @default.
• W2015313445 hasConceptScore W2015313445C98717036 @default.
• W2015313445 hasIssue "5" @default.
• W2015313445 hasLocation W20153134451 @default.
• W2015313445 hasLocation W20153134452 @default.
• W2015313445 hasOpenAccess W2015313445 @default.
• W2015313445 hasPrimaryLocation W20153134451 @default.
• W2015313445 hasRelatedWork W2025170339 @default.
• W2015313445 hasRelatedWork W2046600857 @default.
• W2015313445 hasRelatedWork W2068408721 @default.
• W2015313445 hasRelatedWork W2093476509 @default.
• W2015313445 hasRelatedWork W2101821182 @default.
• W2015313445 hasRelatedWork W2150216118 @default.
• W2015313445 hasRelatedWork W2334410700 @default.
• W2015313445 hasRelatedWork W2914741089 @default.
• W2015313445 hasRelatedWork W2946548216 @default.

• next