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- W2015315046 abstract "Podoplanin (PDPN), a mucin-type transmembrane glycoprotein specific to the lymphatic system is expressed in a variety of human cancers, and is regarded as a factor promoting tumor progression. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells. PDPN expression was evaluated in primary thyroid carcinomas and thyroid carcinoma cell lines by RT-qPCR, Western blotting, IF and IHC. To examine the role of podoplanin in determining a cell's malignant potential (cellular migration, invasion, proliferation, adhesion, motility, apoptosis), a thyroid cancer cell line with silenced PDPN expression was used. We observed that PDPN was solely expressed in the cancer cells of 40% of papillary thyroid carcinoma (PTC) tissues. Moreover, PDPN mRNA and protein were highly expressed in PTC-derived TPC1 and BcPAP cell lines but were not detected in follicular thyroid cancer derived cell lines. PDPN knock-down significantly decreased cellular invasion, and modestly reduced cell migration, while proliferation and adhesion were not affected. Our results demonstrate that PDPN mediates the invasive properties of cells derived from papillary thyroid carcinomas, suggesting that podoplanin might promote PTC progression." @default.
- W2015315046 created "2016-06-24" @default.
- W2015315046 creator A5016908313 @default.
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- W2015315046 date "2014-05-05" @default.
- W2015315046 modified "2023-10-01" @default.
- W2015315046 title "The Role of Podoplanin in the Biology of Differentiated Thyroid Cancers" @default.
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- W2015315046 doi "https://doi.org/10.1371/journal.pone.0096541" @default.
- W2015315046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4010536" @default.
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