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- W2015319420 abstract "Mouse cells in culture contain two distinct forms of thymidine kinase enzyme activities. These two enzymes have been separated by polyacrylamide gel electrophoresis into a 0.2 Rf and a 0.5 Rf activity. The 0.2 Rf enzyme was found only in actively growing cells, while the 0.5 Rf form of thymidine kinase is the mitochondrial-associated enzyme and is most prominent in resting cells in culture. SV40 infection of these resting cells results in an increased specific activity of only the 0.2 Rf form of this enzyme. SV40 wild-type and SV40 tsBC and tsC mutants stimulated the levels of the 0.2 Rf thymidine kinase in resting cells after viral infection at either the permissive temperature (32°) or the nonpermissive temperature (41°). Five different SV40 tsA mutants (tsA7, 28, 30, 58, and 209) and two different SV40 tsD mutants (tsD202, 270) only stimulated thymidine kinase activity at the permissive temperature. Little or no 0.2 Rf thymidine kinase activity could be detected in tsA or tsD mutant-infected cells at the nonpermissive temperature. The SV40 tsA255 mutant appeared to be an exception to the A mutant class in that it stimulated the 0.2 Rf thymidine kinase activity at both permissive and nonpermissive temperatures. These results indicate that the SV40 A gene product may be required directly, and the D gene product indirectly, in the stimulation of cellular enzyme activities following viral infection." @default.
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- W2015319420 date "1976-08-01" @default.
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- W2015319420 title "The requirement of simian virus 40 gene A product for the stimulation of cellular thymidine kinase activity after viral infection" @default.
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- W2015319420 doi "https://doi.org/10.1016/0042-6822(76)90075-1" @default.
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