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- W2015320368 abstract "Receptor-interacting protein 140 (RIP140) is highly expressed in the brain, and acts in neurons and microglia to affect emotional responses. The present study reveals an additional function of RIP140 in the brain, which is to regulate brain lipid homeostasis via its action in astrocytes. We found forced swim stress (FSS) significantly reduces the expression level of RIP140 and elevates cholesterol content in the brain. Mechanistically, FSS elevates endoplasmic reticulum stress, which suppresses RIP140 expression by increasing microRNA 33 (miR33) that targets RIP140 mRNA’s 3′-untranslated region. Consequentially, cholesterol biosynthesis and export are dramatically increased in astrocyte, the major source of brain cholesterol. These results demonstrate that RIP140 plays an important role in maintaining brain cholesterol homeostasis through, partially, regulating cholesterol metabolism in, and mobilization from, astrocyte. Altering RIP140 levels can disrupt brain cholesterol homeostasis, which may contribute to behavioral stress-induced neurological disorders." @default.
- W2015320368 created "2016-06-24" @default.
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- W2015320368 creator A5061085011 @default.
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- W2015320368 date "2015-05-01" @default.
- W2015320368 modified "2023-10-18" @default.
- W2015320368 title "Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation" @default.
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- W2015320368 doi "https://doi.org/10.1016/j.bbi.2015.02.008" @default.
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