FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015320760> ?p ?o ?g. }

• W2015320760 endingPage "366" @default.
• W2015320760 startingPage "353" @default.
• W2015320760 abstract "The objective of the study is to design oral controlled drug delivery systems for highly water-soluble drugs using guar gum as a carrier in the form of a three-layer matrix tablet. Metoprolol tartrate was chosen as a model drug because of its high water solubility. Matrix tablets containing either 30 (M1), 40 (M2) or 50% (M3) of guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of metoprolol tartrate were prepared by compressing on both sides of guar gum matrix tablet granules of metoprolol tartrate M1, M2 or M3 with either 50 (TL1M1, TL1M2 or TL1M3) or 75 mg (TL2M1, TL2M2 or TL2M3) of guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and subjected to in vitro drug release studies. The amount of metoprolol tartrate released from the matrix and three-layer matrix tablets at different time intervals was estimated by using a HPLC method. Matrix tablets of metoprolol tartrate were unable to provide the required drug release rate. However, the three-layer guar gum matrix tablets (TL2M3) provided the required release rate on par with the theoretical release rate for metoprolol tartrate formulations meant for twice daily administration. The three-layer guar gum matrix tablet (TL2M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 degrees C/75% RH for 6 months. The FT-IR study did not show any possibility of metoprolol tartrate/guar gum interaction with the formulation excipients used in the study. The results indicated that guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as metoprolol tartrate." @default.
• W2015320760 created "2016-06-24" @default.
• W2015320760 creator A5008585809 @default.
• W2015320760 creator A5038946572 @default.
• W2015320760 creator A5081018014 @default.
• W2015320760 date "2002-07-01" @default.
• W2015320760 modified "2023-10-02" @default.
• W2015320760 title "A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate" @default.
• W2015320760 cites W1481809741 @default.
• W2015320760 cites W1485386595 @default.
• W2015320760 cites W1964710897 @default.
• W2015320760 cites W1966365231 @default.
• W2015320760 cites W1972697042 @default.
• W2015320760 cites W1977072597 @default.
• W2015320760 cites W2007311426 @default.
• W2015320760 cites W2018357257 @default.
• W2015320760 cites W2028316425 @default.
• W2015320760 cites W2053063162 @default.
• W2015320760 cites W2058445540 @default.
• W2015320760 cites W2059602593 @default.
• W2015320760 cites W2068686072 @default.
• W2015320760 cites W2078704250 @default.
• W2015320760 cites W2129705731 @default.
• W2015320760 cites W2131715817 @default.
• W2015320760 cites W2132545697 @default.
• W2015320760 cites W2153100666 @default.
• W2015320760 doi "https://doi.org/10.1016/s0378-5173(02)00273-9" @default.
• W2015320760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12100863" @default.
• W2015320760 hasPublicationYear "2002" @default.
• W2015320760 type Work @default.
• W2015320760 sameAs 2015320760 @default.
• W2015320760 citedByCount "84" @default.
• W2015320760 countsByYear W20153207602012 @default.
• W2015320760 countsByYear W20153207602013 @default.
• W2015320760 countsByYear W20153207602014 @default.
• W2015320760 countsByYear W20153207602015 @default.
• W2015320760 countsByYear W20153207602016 @default.
• W2015320760 countsByYear W20153207602017 @default.
• W2015320760 countsByYear W20153207602018 @default.
• W2015320760 countsByYear W20153207602019 @default.
• W2015320760 countsByYear W20153207602020 @default.
• W2015320760 countsByYear W20153207602021 @default.
• W2015320760 countsByYear W20153207602022 @default.
• W2015320760 countsByYear W20153207602023 @default.
• W2015320760 crossrefType "journal-article" @default.
• W2015320760 hasAuthorship W2015320760A5008585809 @default.
• W2015320760 hasAuthorship W2015320760A5038946572 @default.
• W2015320760 hasAuthorship W2015320760A5081018014 @default.
• W2015320760 hasConcept C106487976 @default.
• W2015320760 hasConcept C14029885 @default.
• W2015320760 hasConcept C155574463 @default.
• W2015320760 hasConcept C159985019 @default.
• W2015320760 hasConcept C163588942 @default.
• W2015320760 hasConcept C164705383 @default.
• W2015320760 hasConcept C171250308 @default.
• W2015320760 hasConcept C178790620 @default.
• W2015320760 hasConcept C185592680 @default.
• W2015320760 hasConcept C192562407 @default.
• W2015320760 hasConcept C2776725572 @default.
• W2015320760 hasConcept C2781280847 @default.
• W2015320760 hasConcept C2781430271 @default.
• W2015320760 hasConcept C2909447574 @default.
• W2015320760 hasConcept C31903555 @default.
• W2015320760 hasConcept C43617362 @default.
• W2015320760 hasConcept C71924100 @default.
• W2015320760 hasConcept C77281830 @default.
• W2015320760 hasConcept C88380143 @default.
• W2015320760 hasConcept C88463166 @default.
• W2015320760 hasConceptScore W2015320760C106487976 @default.
• W2015320760 hasConceptScore W2015320760C14029885 @default.
• W2015320760 hasConceptScore W2015320760C155574463 @default.
• W2015320760 hasConceptScore W2015320760C159985019 @default.
• W2015320760 hasConceptScore W2015320760C163588942 @default.
• W2015320760 hasConceptScore W2015320760C164705383 @default.
• W2015320760 hasConceptScore W2015320760C171250308 @default.
• W2015320760 hasConceptScore W2015320760C178790620 @default.
• W2015320760 hasConceptScore W2015320760C185592680 @default.
• W2015320760 hasConceptScore W2015320760C192562407 @default.
• W2015320760 hasConceptScore W2015320760C2776725572 @default.
• W2015320760 hasConceptScore W2015320760C2781280847 @default.
• W2015320760 hasConceptScore W2015320760C2781430271 @default.
• W2015320760 hasConceptScore W2015320760C2909447574 @default.
• W2015320760 hasConceptScore W2015320760C31903555 @default.
• W2015320760 hasConceptScore W2015320760C43617362 @default.
• W2015320760 hasConceptScore W2015320760C71924100 @default.
• W2015320760 hasConceptScore W2015320760C77281830 @default.
• W2015320760 hasConceptScore W2015320760C88380143 @default.
• W2015320760 hasConceptScore W2015320760C88463166 @default.
• W2015320760 hasIssue "2" @default.
• W2015320760 hasLocation W20153207601 @default.
• W2015320760 hasLocation W20153207602 @default.
• W2015320760 hasOpenAccess W2015320760 @default.
• W2015320760 hasPrimaryLocation W20153207601 @default.
• W2015320760 hasRelatedWork W2006155369 @default.
• W2015320760 hasRelatedWork W2015320760 @default.
• W2015320760 hasRelatedWork W2017450153 @default.
• W2015320760 hasRelatedWork W2028411814 @default.
• W2015320760 hasRelatedWork W2082406477 @default.

• next