Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015320807> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2015320807 endingPage "481" @default.
- W2015320807 startingPage "481" @default.
- W2015320807 abstract "The bactericidal defect of CGD PMNs has been partially corrected in previous studies relying on the co-phagocytosis of bacteria and of either glucose oxidase (GO)-coated latex particles or GO-containing liposomes. We investigated the effect of opsonization of bacteria with an IgG-GO conjugate upon the bactericidal activity of CGD PMNs and monocytes (MC). Anti-staphylococcal rabbit IgG was prepared and conjugated to GO by diethylmalonimidation. The conjugate (final concentration of IgG: 2.0 mg/ml) was used to opsonize bacteria which were then ingested by PMNs or MCs of female CGD carriers. In control preparations IgG alone was used as opsonin. After 120 minutes of incubation with CGD PMNs, the number of surviving intracellular bacteria decreased from a mean of 42.3% (opsonin: IgG) to 17.7% (opsonin: IgG-GO conjugate). In MCs of CGD carriers the number of intracellular bacteria decreased by 45%. In PMN-free preparation the IgG-GO conjugate displayed negligible bactericidal activity. The bactericidal defect of CGD phagocytic cells can be successfully corrected by the intracellular introduction of an IgG-GO conjugate. Furthermore, such restoration of bactericidal activity may be enhanced by the close proximity between the bacteria and the hydrogen peroxide-generating opsonin." @default.
- W2015320807 created "2016-06-24" @default.
- W2015320807 creator A5054388901 @default.
- W2015320807 creator A5059182955 @default.
- W2015320807 creator A5081557279 @default.
- W2015320807 date "1978-04-01" @default.
- W2015320807 modified "2023-09-27" @default.
- W2015320807 title "704 CORRECTION OF NEUTROPHIL (PMN) DYSFUNCTION IN CHRONIC GRANULOMATOUS DISEASE (CGD) WITH AN IgG-OXIDASE CONJUGATE" @default.
- W2015320807 doi "https://doi.org/10.1203/00006450-197804001-00709" @default.
- W2015320807 hasPublicationYear "1978" @default.
- W2015320807 type Work @default.
- W2015320807 sameAs 2015320807 @default.
- W2015320807 citedByCount "0" @default.
- W2015320807 crossrefType "journal-article" @default.
- W2015320807 hasAuthorship W2015320807A5054388901 @default.
- W2015320807 hasAuthorship W2015320807A5059182955 @default.
- W2015320807 hasAuthorship W2015320807A5081557279 @default.
- W2015320807 hasBestOaLocation W20153208071 @default.
- W2015320807 hasConcept C134306372 @default.
- W2015320807 hasConcept C159654299 @default.
- W2015320807 hasConcept C160448771 @default.
- W2015320807 hasConcept C168507396 @default.
- W2015320807 hasConcept C181199279 @default.
- W2015320807 hasConcept C185592680 @default.
- W2015320807 hasConcept C197336794 @default.
- W2015320807 hasConcept C203014093 @default.
- W2015320807 hasConcept C2777700362 @default.
- W2015320807 hasConcept C2778175462 @default.
- W2015320807 hasConcept C2779719074 @default.
- W2015320807 hasConcept C2780898057 @default.
- W2015320807 hasConcept C33923547 @default.
- W2015320807 hasConcept C523546767 @default.
- W2015320807 hasConcept C54355233 @default.
- W2015320807 hasConcept C55493867 @default.
- W2015320807 hasConcept C79879829 @default.
- W2015320807 hasConcept C86803240 @default.
- W2015320807 hasConcept C89372155 @default.
- W2015320807 hasConcept C89423630 @default.
- W2015320807 hasConceptScore W2015320807C134306372 @default.
- W2015320807 hasConceptScore W2015320807C159654299 @default.
- W2015320807 hasConceptScore W2015320807C160448771 @default.
- W2015320807 hasConceptScore W2015320807C168507396 @default.
- W2015320807 hasConceptScore W2015320807C181199279 @default.
- W2015320807 hasConceptScore W2015320807C185592680 @default.
- W2015320807 hasConceptScore W2015320807C197336794 @default.
- W2015320807 hasConceptScore W2015320807C203014093 @default.
- W2015320807 hasConceptScore W2015320807C2777700362 @default.
- W2015320807 hasConceptScore W2015320807C2778175462 @default.
- W2015320807 hasConceptScore W2015320807C2779719074 @default.
- W2015320807 hasConceptScore W2015320807C2780898057 @default.
- W2015320807 hasConceptScore W2015320807C33923547 @default.
- W2015320807 hasConceptScore W2015320807C523546767 @default.
- W2015320807 hasConceptScore W2015320807C54355233 @default.
- W2015320807 hasConceptScore W2015320807C55493867 @default.
- W2015320807 hasConceptScore W2015320807C79879829 @default.
- W2015320807 hasConceptScore W2015320807C86803240 @default.
- W2015320807 hasConceptScore W2015320807C89372155 @default.
- W2015320807 hasConceptScore W2015320807C89423630 @default.
- W2015320807 hasLocation W20153208071 @default.
- W2015320807 hasOpenAccess W2015320807 @default.
- W2015320807 hasPrimaryLocation W20153208071 @default.
- W2015320807 hasRelatedWork W1821121474 @default.
- W2015320807 hasRelatedWork W1848183260 @default.
- W2015320807 hasRelatedWork W1949580066 @default.
- W2015320807 hasRelatedWork W1994502472 @default.
- W2015320807 hasRelatedWork W2116738903 @default.
- W2015320807 hasRelatedWork W2131107336 @default.
- W2015320807 hasRelatedWork W2136825112 @default.
- W2015320807 hasRelatedWork W2138215354 @default.
- W2015320807 hasRelatedWork W2154042049 @default.
- W2015320807 hasRelatedWork W2186834780 @default.
- W2015320807 hasVolume "12" @default.
- W2015320807 isParatext "false" @default.
- W2015320807 isRetracted "false" @default.
- W2015320807 magId "2015320807" @default.
- W2015320807 workType "article" @default.