Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015325381> ?p ?o ?g. }
- W2015325381 endingPage "e45711" @default.
- W2015325381 startingPage "e45711" @default.
- W2015325381 abstract "Progressive reduction in β-cell mass is responsible for the development of type 2 diabetes mellitus, and alteration in insulin receptor substrate 2 (IRS-2) abundance plays a critical role in this process. IRS-2 expression is stimulated by the transcription factor cAMP response element-binding protein (CREB) and we recently demonstrated that Ca2+/calmodulin dependent kinase 4 (CaMK4) is upstream of CREB activation in β-cells. This study investigated whether CaMK4 is also a potential target to increase β-cell mass through CREB-mediated IRS-2 expression, by quantifying mouse MIN6 β-cell proliferation and apoptosis following IRS-2 knockdown, CaMKs inhibition and alterations in CaMK4 and CREB expression. Expression of constitutively active CaMK4 (ΔCaMK4) and CREB (CREBDIEDLM) significantly stimulated β-cell proliferation and survival. In contrast, expression of their corresponding dominant negative forms (ΔK75ECaMK4 and CREBM1) and silencing of IRS-2 increased apoptosis and reduced β-cell division. Moreover, CREBDIEDLM and CREBM1 expression completely abolished the effects of ΔK75ECaMK4 and of ΔCaMK4, respectively. Our results indicate that CaMK4 regulates β-cell proliferation and apoptosis in a CREB-dependent manner and that CaMK4-induced IRS-2 expression is important in these processes." @default.
- W2015325381 created "2016-06-24" @default.
- W2015325381 creator A5021777528 @default.
- W2015325381 creator A5045593096 @default.
- W2015325381 creator A5054447877 @default.
- W2015325381 creator A5068567368 @default.
- W2015325381 creator A5074801875 @default.
- W2015325381 date "2012-09-25" @default.
- W2015325381 modified "2023-10-13" @default.
- W2015325381 title "The CaMK4/CREB/IRS-2 Cascade Stimulates Proliferation and Inhibits Apoptosis of β-Cells" @default.
- W2015325381 cites W1511319154 @default.
- W2015325381 cites W1532025074 @default.
- W2015325381 cites W1614322283 @default.
- W2015325381 cites W1657478053 @default.
- W2015325381 cites W1697523131 @default.
- W2015325381 cites W1965722126 @default.
- W2015325381 cites W1968646619 @default.
- W2015325381 cites W1971851666 @default.
- W2015325381 cites W1981114929 @default.
- W2015325381 cites W1982391086 @default.
- W2015325381 cites W1983513002 @default.
- W2015325381 cites W1985105947 @default.
- W2015325381 cites W1987740077 @default.
- W2015325381 cites W1988760852 @default.
- W2015325381 cites W2000240015 @default.
- W2015325381 cites W2004470953 @default.
- W2015325381 cites W2015413597 @default.
- W2015325381 cites W2022990574 @default.
- W2015325381 cites W2024992738 @default.
- W2015325381 cites W2034712114 @default.
- W2015325381 cites W2035940741 @default.
- W2015325381 cites W2038961236 @default.
- W2015325381 cites W2042481436 @default.
- W2015325381 cites W2064226140 @default.
- W2015325381 cites W2069065093 @default.
- W2015325381 cites W2070485157 @default.
- W2015325381 cites W2071750527 @default.
- W2015325381 cites W2076686929 @default.
- W2015325381 cites W2077556683 @default.
- W2015325381 cites W2086547011 @default.
- W2015325381 cites W2091994574 @default.
- W2015325381 cites W2093478842 @default.
- W2015325381 cites W2109447054 @default.
- W2015325381 cites W2110166408 @default.
- W2015325381 cites W2113544353 @default.
- W2015325381 cites W2114677291 @default.
- W2015325381 cites W2126241549 @default.
- W2015325381 cites W2130663011 @default.
- W2015325381 cites W2132557269 @default.
- W2015325381 cites W2138463340 @default.
- W2015325381 cites W2141063928 @default.
- W2015325381 cites W2146921827 @default.
- W2015325381 cites W2153977812 @default.
- W2015325381 cites W2165991181 @default.
- W2015325381 doi "https://doi.org/10.1371/journal.pone.0045711" @default.
- W2015325381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3458088" @default.
- W2015325381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23049845" @default.
- W2015325381 hasPublicationYear "2012" @default.
- W2015325381 type Work @default.
- W2015325381 sameAs 2015325381 @default.
- W2015325381 citedByCount "49" @default.
- W2015325381 countsByYear W20153253812013 @default.
- W2015325381 countsByYear W20153253812014 @default.
- W2015325381 countsByYear W20153253812015 @default.
- W2015325381 countsByYear W20153253812016 @default.
- W2015325381 countsByYear W20153253812017 @default.
- W2015325381 countsByYear W20153253812018 @default.
- W2015325381 countsByYear W20153253812019 @default.
- W2015325381 countsByYear W20153253812020 @default.
- W2015325381 countsByYear W20153253812021 @default.
- W2015325381 countsByYear W20153253812022 @default.
- W2015325381 countsByYear W20153253812023 @default.
- W2015325381 crossrefType "journal-article" @default.
- W2015325381 hasAuthorship W2015325381A5021777528 @default.
- W2015325381 hasAuthorship W2015325381A5045593096 @default.
- W2015325381 hasAuthorship W2015325381A5054447877 @default.
- W2015325381 hasAuthorship W2015325381A5068567368 @default.
- W2015325381 hasAuthorship W2015325381A5074801875 @default.
- W2015325381 hasBestOaLocation W20153253811 @default.
- W2015325381 hasConcept C104317684 @default.
- W2015325381 hasConcept C119056186 @default.
- W2015325381 hasConcept C1629964 @default.
- W2015325381 hasConcept C173396325 @default.
- W2015325381 hasConcept C190283241 @default.
- W2015325381 hasConcept C55493867 @default.
- W2015325381 hasConcept C62112901 @default.
- W2015325381 hasConcept C86339819 @default.
- W2015325381 hasConcept C86803240 @default.
- W2015325381 hasConcept C95444343 @default.
- W2015325381 hasConceptScore W2015325381C104317684 @default.
- W2015325381 hasConceptScore W2015325381C119056186 @default.
- W2015325381 hasConceptScore W2015325381C1629964 @default.
- W2015325381 hasConceptScore W2015325381C173396325 @default.
- W2015325381 hasConceptScore W2015325381C190283241 @default.
- W2015325381 hasConceptScore W2015325381C55493867 @default.
- W2015325381 hasConceptScore W2015325381C62112901 @default.
- W2015325381 hasConceptScore W2015325381C86339819 @default.
- W2015325381 hasConceptScore W2015325381C86803240 @default.