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• W2015326068 abstract "Objective COX-2, the inducible isoenzyme, was found to be overexpressed in approximately 85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 polymorphisms that might modify the levels of protein expression would be anticipated to have a substantial influence on disease phenotype. Therefore, we sought to understand the role of three COX-2 polymorphisms (−1195A>G, −765G>C, and 8473T>C) in colorectal cancer (CRC) onset. Material and methods We conducted a hospital-based case–control study involving 117 consecutively enrolled CRC patients and 256 healthy individuals without any clinical evidence of cancer. The COX-2 polymorphisms' genotypes were characterized by PCR-restriction fragment length polymorphism or real-time PCR techniques. Results The −1195A>G polymorphism was associated with a 1.73-fold increased predisposition to CRC onset. In a stratified analysis, men and ever-smokers carrying –1195G allele (AG+GG) had an increased risk for CRC development (odds ratio: 2.58; 95% confidence intraval: 1.29–5.15 and odds ratio: 10.3; 95% confidence intraval: 3.37–31.2, respectively). More interestingly, men ever-smokers carrying –1195G allele appeared to have a nine-fold increased risk for CRC onset (95% CI: 2.94–27.6). No difference in the genotype's distribution was noticed between cases and controls for the remaining two polymorphisms. Conclusion The −1195A>G COX-2 polymorphism seems to modulate the genetic susceptibility for CRC onset, especially in men ever-smokers. This genetically based higher-risk group definition may help shift the balance between risk and benefits for the use of COX-2 inhibitors in chemoprevention that is currently hampered by the adverse gastrointestinal and cardiovascular side-effects." @default.
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• W2015326068 date "2010-05-01" @default.
• W2015326068 modified "2023-09-27" @default.
• W2015326068 title "COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention" @default.
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• W2015326068 doi "https://doi.org/10.1097/meg.0b013e3283352cbb" @default.
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